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Journal of Cell Science, Vol 35, Issue 1 403-415, Copyright © 1979 by Company of Biologists

JOURNAL ARTICLES

Production and fate of erythroid cells in anaemic Xenopus laevis

N Chegini, V Aleporou, G Bell, VA Hilder and N Maclean

Adult Xenopus laevis, rendered anaemic by phenylhydrazine injection, have been studied during the recovery from such anaemia. Electron microscopy of liver and spleen sections indicates that both of these organs are active in the phagocytosis and destruction of the old damaged red blood cells. May-Grunwald and Giemsa staining of liver and spleen cells following anaemia has been used to show that erythropoiesis also occurs in both liver and spleen, and this has been confirmed by electron-microscope studies of these organs. Cell counting and radiolabelling of the new population of circulating erythroid cells in the period following phenylhydrazine injection suggests that a sudden release of basophilic erythroblasts from liver and spleen is followed by mitosis of this new cell population in circulation, and that no further release of erythroid cells from these organs is likely until complete recovery has occurred.




© The Company of Biologists Ltd 1979