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Journal of Cell Science, Vol 34, Issue 1 233-246, Copyright © 1978 by Company of Biologists


JOURNAL ARTICLES

DNA-binding properties of nuclear matrix proteins

DE Comings and AS Wallack

Mouse nuclear matrix proteins, examined by a filter assay, were found to bind to DNA. There was no preference for homologous mouse compared to heterologous E. coli DNA. Competition assays showed a preference for AT-rich DNA and of the 4 single-stranded homopolymers there was a preference for poly(dT). These observations are consistent with the possibility that the matrix may play a role in the formation of AT-rich chromomeres (G-bands).





© The Company of Biologists Ltd 1978