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Journal of Cell Science, Vol 33, Issue 1 301-316, Copyright © 1978 by Company of Biologists

JOURNAL ARTICLES

Membrane changes associated with mucus production by intestinal goblet cells

JG Swift and TM Mukherjee

Changes in the structural organization of membranes of mucous bodies and the plasma membrane that occur during mucus production in goblet cells of rat rectum have been studied by thin-section and freeze-fracture techniques. Immature mucous bodies are bounded by a trilaminar membrane and fracture faces of the membrane have randomly distributed intramembrane particles. During maturation, mucous bodies become packed tightly together and changes in the structure of their membranes include (1) fusion of apposing membranes of adjacent bodies to form a pentalaminar structure, (2) a reduction in the density of particles on membrane fracture faces, and (3) exclusion of particles from regions of membrane apposition. Some trilaminar membranes of mucous bodies fuse with the lumenal plasma membrane to form a pentalaminar structure. Sites of apposition between mucous body membranes and the lumenal plasma membrane are seen as particle-cleared bulges on fracture faces of the plasma membrane. Our results indicate that membrane reorganization associated with mucous production in goblet cells includes a reduction and redistribution of some membrane proteins and that membrane fusion occurs between portions of membranes from which proteins have been displaced.


This article has been cited by other articles:


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 J. Histochem. Cytochem.Home page
I. Leverkoehne and A. D. Gruber
The Murine mCLCA3 (Alias gob-5) Protein Is Located in the Mucin Granule Membranes of Intestinal, Respiratory, and Uterine Goblet Cells
J. Histochem. Cytochem., June 1, 2002; 50(6): 829 - 838.
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© The Company of Biologists Ltd 1978