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Journal of Cell Science, Vol 33, Issue 1 1-16, Copyright © 1978 by Company of Biologists

JOURNAL ARTICLES

Computer simulation of aggregation in Dictyostelium discoideum

SA MacKay

The aggregation phase of development of the cellular slime mould Dictyostelium discoideum is simulated on a computer. The simulation is performed in 2 dimensions, and produces animated graphical output similar to time-lapse films. It is based on observations of cell behaviour as expressed by a set of rules for each cell, involving cell movement and release of and response to chemical signals. Following these rules, the simulation has reproduced many observed aggregation patterns: propagating waves of cell movement; formation of branching streams; entrainment of slower centres; and spiral centre formation. The simulation has proved to be an important adjunct to experimental work.


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© The Company of Biologists Ltd 1978