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Journal of Cell Science, Vol 32, Issue 1 137-151, Copyright © 1978 by Company of Biologists

JOURNAL ARTICLES

The induction of the acrosome reaction in guinea-pig sperm by the divalent metal cation ionophore A23187

DP Green

The divalent metal cation ionophore A23187 induces an acrosome reaction in guinea-pig sperm which is dependent on external calcium. Examination of this acrosome reaction by electron microscopy shows that it is morphologically normal. The known properties of A23187 and the morphological similarity between the acrosome reaction and the secretory discharges of other secretory cells suggests that the immediate cause of the acrosome reaction is an increase in the cytoplasmic free calcium concentration.


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© The Company of Biologists Ltd 1978