spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sudbery, P. E.
Right arrow Articles by Grant, W. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sudbery, P. E.
Right arrow Articles by Grant, W. D.

Journal of Cell Science, Vol 22, Issue 1 59-65, Copyright © 1976 by Company of Biologists

JOURNAL ARTICLES

The control of mitosis in Physarum polycephalum: the effect of delaying mitosis and evidence for the operation of the control mechanism in the absence of growth

PE Sudbery and WD Grant

Possible mechanisms coordinating the control of mitosis and DNA synthesis with growth were experimentally tested in Physarum polycephalum by the response of plasmodia to 2 different kinds of perturbation of the DNA:mass ratio. Mitosis and DNA synthesis were delayed without stopping growth either by the use of fluorodeoxyuridine (FUdR) or puromycin, in both cases the delayed mitosis was followed by a single shortened intermitotic period, as predicted by all the mechanisms considered and substantiating a basic assumption made that the time of mitosis is homeostatically controlled to maintain a constant DNA:mass ratio. When more than 50% of the DNA was destroyed by ultraviolet irradiation 2 consecutive mitoses could occur even when growth was completely stopped by starvation. This result can only be accounted for by 2 of the 5 models considered, a finding which agrees with the results of previous experiments which were also consistent with only these 2 mechanisms.


This article has been cited by other articles:


Home page
 Plant Cell PhysiolHome page
A. C. M. Kwok and J. T. Y. Wong
Lipid Biosynthesis and its Coordination with Cell Cycle Progression
Plant Cell Physiol., December 1, 2005; 46(12): 1973 - 1986.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1976