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Journal of Cell Science, Vol 2, 545-555, Copyright © 1967 by Company of Biologists

Submitted on May 5, 1967

Studies on the Mechanism of Substrate Induction and L-Cyst(e)ine Repression of Alkaline Phosphatase in Mammalian Cell Cultures

M. J. GRIFFIN 1 and R. P. COX 2

1 Department of Medicine, New York University Medical Centre, New York, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104.
2 Department of Medicine, New York University Medical Centre, New York

The mechanisms of substrate induction and L-cyst(e)ine repression of alkaline phosphatase were studied in tissue culture using an established African green monkey kidney cell line (BS-C-I). L-Cyst(e)ine repression and substrate induction are mutually antagonistic. Evidence is presented which suggests that the increase in alkaline phosphatase levels induced by mono-phosphate esters may in part be due to protection of the enzyme from cellular degradation, while L-cyst(e)ine is believed to act either by repressing the synthesis of the enzyme or by selectively increasing its catabolism.

Submitted on May 5, 1967






© The Company of Biologists Ltd 1967