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Journal of Cell Science, Vol 2, 371-376, Copyright © 1967 by Company of Biologists

Submitted on September 9, 1966
Revised on February 10, 1967

An Electron-Microscope Study of the In Vitro Transformation of Human Leucocytes

II. Transformation to Macrophages

J. A. CHAPMAN 1, J. GOUGH 2, and M. W. ELVES 3

1 Rheumatism Research Centre, University of Manchester, and Department of Clinical Haematology, The Royal Infirmary, Manchester
2 Rheumatism Research Centre, University of Manchester, and Department of Clinical Haematology, The Royal Infirmary, Manchester; Department of Pathology, University of Manchester
3 Rheumatism Research Centre, University of Manchester, and Department of Clinical Haematology, The Royal Infirmary, Manchester; The Charles Salt Research Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Salop

Macrophages which develop in cultures of human peripheral blood have the typical ultrastructural features of macrophages occurring in other situations, in vivo and in vitro. The cultured cells usually have irregular nuclei and the cytoplasm possesses numerous digestion vacuoles containing debris; the cell outline is irregular with many filopodia. Other cells were laden with membrane-bounded granular bodies containing periodic-structured material of regular outline. Although it is concluded that no evidence about cell ancestry can be adduced from this morphological study, it seems likely from other work that many of these macrophages arise from lymphocytes.

Submitted on September 9, 1966
Revised on February 10, 1967






© The Company of Biologists Ltd 1967