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Journal of Cell Science, Vol 2, 309-322, Copyright © 1967 by Company of Biologists

Revised on January 30, 1967

Interaction Between Normal and Transformed Bovine Fibroblasts in Culture

I. Cells Transformed by Rous Sarcoma Virus

ELIZABETH MACINTYRE 1 and J. PONTÉN 2

1 Group of Cell Biology, The Wallenberg Laboratory, University of Uppsala Uppsala, Sweden; Pathology Department, University of Colorado, Medical Center, Denver, Colorado, 80220, U.S.A.
2 Group of Cell Biology, The Wallenberg Laboratory, University of Uppsala Uppsala, Sweden; Department of Pathology, University of Uppsala, Uppsala, Sweden

Base layers of untransformed normal embryonic lung fibroblasts in different stages of growth were challenged with RSV (Rous sarcoma virus)-transformed bovine fibroblasts. The effect of this admixture on the growth of the RSV-transformed cells was studied. In all cases, the transformed cells proliferated freely, and it is concluded that the normal cells exerted no inhibition on the transformed cells.

Revised on January 30, 1967






© The Company of Biologists Ltd 1967