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Journal of Cell Science, Vol 17, Issue 3 531-538, Copyright © 1975 by Company of Biologists

JOURNAL ARTICLES

Effects of discrete nuclear u.v-microbeam irradiation on herpes virus and SV40 infection

II Deak and V Defendi

The requirement for a nucleolus in the expression of structural genes of nuclear viruses was examined by means of experiments in which the nucleolus or other parts of the nucleus was inactivated by a microbean of unltraviolet light. These experiments showed that the expression of such genes is not dependent on cucleolar function. This conclusion is discussed in the light of previous experiments in which similar inactiviation of nucleolus was shown to prevent the expression of cellular structural genes.




© The Company of Biologists Ltd 1975