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Journal of Cell Science, Vol 16, 401-419, Copyright © 1974 by Company of Biologists

Submitted on March 4, 1974

Contact Inhibition of Overlapping and Differential Cell Adhesion: A Sufficient Model for the Control of Certain Cell Culture Morphologies

E. MARTZ 1, H. M. PHILLIPS 2, and M. S. STEINBERG 3

1 Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, U.S.A.
2 Department of Biology, University of Virginia, Charlottesville, Virginia 22903, U.S.A.
3 Department of Biology, Princeton University, Princeton, New Jersey 08540, U.S.A.

Using intuitive arguments, several investigators have proposed that the relative strengths of adhesion of cell to cell and of cell to substratum could determine whether or not monolayering - and specifically contact inhibition of cell overlapping - will occur. In the present communication, these ‘strengths of adhesion’ are given precise physical definitions, and the adhesive relationships which would promote spontaneous cell monolayering are rigorously derived, using the thermodynamic approach embodied in the differential adhesion hypothesis. This analysis verifies that contact inhibition of overlapping could, in principle, be a result solely of differential adhesion. In addition, it is demonstrated that for homogeneous populations of uniform cells cultured on a solid, uniform substratum, eleven distinct equilibrium configurations (cell population morphologies) could be generated merely by varying the relative values of cell-to-cell and cell-to-substratum adhesiveness. Most of these configurations have been observed previously in actual cell cultures.

Submitted on March 4, 1974




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© The Company of Biologists Ltd 1974