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First published online 18 March 2008
doi: 10.1242/jcs.021105

Journal of Cell Science 121, 1165-1171 (2008)
Published by The Company of Biologists 2008
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Research Article

A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-{kappa}B

Romania Stilo1,4, Ettore Varricchio1, Domenico Liguoro2, Antonio Leonardi3 and Pasquale Vito1,4,*

1 Dip. Scienze Biologiche ed Ambientali, Università degli Studi del Sannio di Benevento, Via Port'Arsa 11, 82100 Benevento, Italy
2 Centro di Endocrinologia ed Oncologia Sperimentale, Napoli, Italy
3 Dip. di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli `Federico II', Via S. Pansini 5, 80131, Napoli, Italy
4 BioGeM Consortium, Via Camporeale, 83031 Ariano Irpino, Italy

* Author for correspondence (e-mail: vito{at}unisannio.it)

Accepted 14 January 2008

The molecular complex containing CARMA proteins, BCL10 and TRAF6 has been identified recently as a key component in the signal transduction pathways that regulate activation of the nuclear factor {kappa}B (NF-{kappa}B) transcription factor. Here, we report that the inducible protein A20 negatively regulates these signaling cascades by means of its deubiquitylation activity. We show that A20 perturbs assembly of the complex containing CARMA3, BCL10 and IKK{gamma}/NEMO, thereby suppressing activation of NF-{kappa}B. Together, our results further define the molecular mechanisms that control activation of NF-{kappa}B and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells.

Key words: A20, BCL10, CARMA




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[Abstract] [Full Text] [PDF]


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