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First published online April 23, 2007
doi: 10.1242/10.1242/jcs.005975

Journal of Cell Science 120, 1505-1511 (2007)
Published by The Company of Biologists 2007
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Commentary

Epithelial tight junctions, gene expression and nucleo-junctional interplay

Karl Matter and Maria Susana Balda

Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK

e-mail: k.matter{at}ucl.ac.uk; m.balda{at}ucl.ac.uk

Accepted 6 March 2007

Tight junctions are components of the junctional complex linking neighbouring epithelial cells and are important for barrier formation. Recent evidence suggests that tight junctions also participate in signal transduction mechanisms that regulate epithelial cell proliferation, gene expression, differentiation and morphogenesis. One important class of tight-junction-associated signal transduction mechanism is based on dual localisation of certain proteins both at junctions and in the nucleus. These proteins and their partners participate in various steps of gene expression, ranging from regulation of transcription and chromatin structure to mRNA processing and translation. In cancer tissues, their expression is often deregulated in a manner that suggests that tight junctions function as suppressors of proliferation and transformation.

Key words: Y-box factor, ZO-1, ZO-2, Symplekin, SAF-B, AP-1




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