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Journal of Cell Science, Vol 12, 911-923, Copyright © 1973 by Company of Biologists

Submitted on August 3, 1972

Acetylcholinesterase in Human Erythroid Cells

R. J. SKAER 1

1 Department of Medicine, University of Cambridge, Hills Road, Cambridge, England

Acetylcholinesterase is present in human red cells but cannot be demonstrated by the copper thiocholine test. The enzyme is revealed, however, in the perinuclear cisterna, endoplasmic reticulum and Golgi apparatus of red cell precursors. It is suggested that 2 forms of the enzyme are present, one of which can be demonstrated by the copper thiocholine test, the other cannot; one form may be the precursor of the other. These observations may cast light on the kinetics of red cell replacement and on the interpretation of the results from the copper thiocholine test on other tissues such as the nervous system.

Submitted on August 3, 1972






© The Company of Biologists Ltd 1973