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Journal of Cell Science, Vol 12, 903-909, Copyright © 1973 by Company of Biologists

Submitted on August 14, 1972

The Effects of Fasting and Feeding on the Protein Synthesis Rate and Polyribosomal Profile of Frog Pepsinogenic Cells

W. J. VAN VENROOIJ 1, C. POORT 2, and J. J. GEUZE 2

1 Laboratory of Histology and Cell Biology and the Centre for Electronmicroscopy, Medical Faculty, State University of Utrecht, Utrecht, The Netherlands; Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
2 Laboratory of Histology and Cell Biology and the Centre for Electronmicroscopy, Medical Faculty, State University of Utrecht, Utrecht, The Netherlands

1. The rate of [14C]leucine incorporation into the protein of frog pepsinogenic cells was measured in both fasted and fed animals. The incorporation rate increases after feeding, becoming maximal after 2 h.

2. In the oesophagi of fasted frogs, only monoribosomes and dimers are present. The absence of polyribosomes is not due to autolysis in the homogenate. After feeding, heavy polyribosomal aggregates appear.

3. It is concluded that feeding stimulates protein synthesis in frog pepsinogenic cells.

Submitted on August 14, 1972






© The Company of Biologists Ltd 1973