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Journal of Cell Science, Vol 12, 861-873, Copyright © 1973 by Company of Biologists

Submitted on July 13, 1972

Studies on Contact Inhibition of Growth in the Mouse Fibroblast, 3T3

II. Effects of Amino Acid Deprivation and Serum on Growth Rate

A. I. MEISLER 1

1 Department of Medicine and Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, U.S.A.

The effect of amino acid concentration on the initial growth rate of the contact-inhibited mouse fibroblasts 3T3 and its SV40-transformed derivative 3T3T has been studied. In medium in which the serum had been passed through a Sephadex column, and the concentration of amino acids lowered 1000-fold, one acid at a time, the growth rate constants were computed. For most of the 16 amino acids studied, the initial growth rate of 3T3 decreased more profoundly than that of 3T3T. The presence in serum of a factor which stimulates amino acid uptake and growth rate of 3T3T is described.

Submitted on July 13, 1972






© The Company of Biologists Ltd 1973