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Journal of Cell Science, Vol 12, 655-664, Copyright © 1973 by Company of Biologists

Submitted on June 12, 1972

Some Effects of Actinomycin D, Cycloheximide and Puromycin on Cell Adhesion

L. WEISS 1 and M. K. CHANG 1

1 Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, N.Y. 14203, U.S.A.

The metabolic inhibitors cycloheximide, puromycin and actinomycin D, increased the rate of adhesion of Ehrlich ascites tumour cells to coverslips and plastic surfaces, over periods of up to 2 h in vitro. Among a number of possible explanations of this effect is a decreased production of hypothetical anti-adhesion factor(s). It is suggested that the difference between the increased rate of adhesion observed by us, and the decrease or lack of effect of the drugs observed by others, is related to prior trypsin-treatment of cells by the other observers.

Submitted on June 12, 1972






© The Company of Biologists Ltd 1973