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First published online December 11, 2006
doi: 10.1242/10.1242/jcs.03295

Journal of Cell Science 119, 5021-5029 (2006)
Published by The Company of Biologists 2006
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Commentary

KASH-domain proteins in nuclear migration, anchorage and other processes

Kevin Wilhelmsen, Mirjam Ketema, Hoa Truong and Arnoud Sonnenberg*

Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

* Author for correspondence (e-mail: a.sonnenberg{at}nki.nl)

Accepted 30 August 2006

The nucleus in eukaryotic cells can move within the cytoplasm, and its position is crucial for many cellular events, including migration and differentiation. Nuclear anchorage and movement can be achieved through association of outer nuclear membrane (ONM) proteins with the three cytoskeletal systems. Two decades ago studies described C. elegans mutants with defects in such events, but only recently has it been shown that the strategies for nuclear positioning are indeed conserved in C. elegans, Drosophila, mammals and potentially all eukaryotes. The integral ONM proteins implicated in these processes thus far all contain a conserved Klarsicht/ANC-1/Syne homology (KASH) domain at their C-terminus that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE). The complex thus formed is responsible not only for association with cytoplasmic elements but also for the integrity of the NE itself.

Key words: Nuclear envelope, Outer nuclear membrane, KASH domain, Nesprin




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