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First published online October 12, 2006
doi: 10.1242/10.1242/jcs.03227

Journal of Cell Science 119, 4155-4163 (2006)
Published by The Company of Biologists 2006
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Commentary

Generation of noncentrosomal microtubule arrays

Francesca Bartolini and Gregg G. Gundersen*

Departments of Anatomy & Cell Biology and Pathology, Columbia University, New York, NY 10032, USA

* Author for correspondence (e-mail: ggg1{at}columbia.edu)

Accepted 23 August 2006

In most proliferating and migrating animal cells, the centrosome is the main site for microtubule (MT) nucleation and anchoring, leading to the formation of radial MT arrays in which MT minus ends are anchored at the centrosomes and plus ends extend to the cell periphery. By contrast, in most differentiated animal cell types, including muscle, epithelial and neuronal cells, as well as most fungi and vascular plant cells, MTs are arranged in noncentrosomal arrays that are non-radial. Recent studies suggest that these noncentrosomal MT arrays are generated by a three step process. The initial step involves formation of noncentrosomal MTs by distinct mechanisms depending on cell type: release from the centrosome, catalyzed nucleation at noncentrosomal sites or breakage of pre-existing MTs. The second step involves transport by MT motor proteins or treadmilling to sites of assembly. In the final step, the noncentrosomal MTs are rearranged into cell-type-specific arrays by bundling and/or capture at cortical sites, during which MTs acquire stability. Despite their relative stability, the final noncentrosomal MT arrays may still exhibit dynamic properties and in many cases can be remodeled.

Key words: Microtubules, Centrosome, S. pombe, Myotubes, Neurons, Epithelia, Plants




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