|
|
|
|
|
||
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online October 12, 2006
doi: 10.1242/10.1242/jcs.03226
Commentary |
-tubulin and beyond
1 Department of Biochemistry, University of Wisconsin–Madison, 433 Babcock Drive, Madison, WI 53706, USA
2 HHMI and Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, MD 21218, USA
* Author for correspondence (e-mail: wiese{at}biochem.wisc.edu)
Accepted 23 August 2006
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of microtubules. Recent work has improved our understanding of the molecular mechanisms of MT formation. In particular, it has shown that 
-tubulin and its associated proteins play key roles in microtubule nucleation and spindle assembly in evolutionarily distant species ranging from fungi to mammals. Other work indicates that -tubulin-mediated microtubule nucleation, although necessary, is not sufficient for mitotic spindle assembly but requires additional proteins that regulate microtubule nucleation independently of centrosomes.
Key words: Centrosome, -tubulin, Microtubule, Nucleation, XMAP215, TACC, TPX2, Aurora A
This article has been cited by other articles:
|
|
 |
|
  L. Guo, C.-M. K. Ho, Z. Kong, Y.-R. J. Lee, Q. Qian, and B. Liu Evaluating the microtubule cytoskeleton and its interacting proteins in monocots by mining the rice genome Ann. Bot., December 23, 2008; (2008) mcn248v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhu, J. A. Coppinger, C.-Y. Jang, J. R. Yates III, and G. Fang FAM29A promotes microtubule amplification via recruitment of the NEDD1-{gamma}-tubulin complex to the mitotic spindle J. Cell Biol., December 1, 2008; 183(5): 835 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Samejima, V. J. Miller, L. M. Groocock, and K. E. Sawin Two distinct regions of Mto1 are required for normal microtubule nucleation and efficient association with the {gamma}-tubulin complex in vivo J. Cell Sci., December 1, 2008; 121(23): 3971 - 3980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Goshima, M. Mayer, N. Zhang, N. Stuurman, and R. D. Vale Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle J. Cell Biol., October 14, 2008; 181(3): 421 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Albee and C. Wiese Xenopus TACC3/Maskin Is Not Required for Microtubule Stability but Is Required for Anchoring Microtubules at the Centrosome Mol. Biol. Cell, August 1, 2008; 19(8): 3347 - 3356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Rogers, N. M. Rusan, M. Peifer, and S. L. Rogers A Multicomponent Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila Cells Mol. Biol. Cell, July 1, 2008; 19(7): 3163 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Izumi, K. Fumoto, S. Izumi, and A. Kikuchi GSK-3{beta} Regulates Proper Mitotic Spindle Formation in Cooperation with a Component of the {gamma}-Tubulin Ring Complex, GCP5 J. Biol. Chem., May 9, 2008; 283(19): 12981 - 12991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Resendes, B. A. Rasala, and D. J. Forbes Centrin 2 Localizes to the Vertebrate Nuclear Pore and Plays a Role in mRNA and Protein Export Mol. Cell. Biol., March 1, 2008; 28(5): 1755 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liu and C. Wiese Xenopus NEDD1 is required for microtubule organization in Xenopus egg extracts J. Cell Sci., March 1, 2008; 121(5): 578 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-W. Fong, Y.-K. Choi, J. B. Rattner, and R. Z. Qi CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the {gamma}-Tubulin Ring Complex Mol. Biol. Cell, January 1, 2008; 19(1): 115 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wiese Distinct Dgrip84 Isoforms Correlate with Distinct {gamma}-Tubulins in Drosophila Mol. Biol. Cell, January 1, 2008; 19(1): 368 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Boutros, V. Lobjois, and B. Ducommun CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule Nucleation Cancer Res., December 15, 2007; 67(24): 11557 - 11564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Nguyen, C. Eichwald, M. L. Nibert, and K. Munger Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component {gamma}-Tubulin J. Virol., December 15, 2007; 81(24): 13533 - 13543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang and T. L. Megraw Proper Recruitment of {gamma}-Tubulin and D-TACC/Msps to Embryonic Drosophila Centrosomes Requires Centrosomin Motif 1 Mol. Biol. Cell, October 1, 2007; 18(10): 4037 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Albee, W. Tao, and C. Wiese Phosphorylation of Maskin by Aurora-A Is Regulated by RanGTP and Importin beta J. Biol. Chem., December 15, 2006; 281(50): 38293 - 38301. [Abstract] [Full Text] [PDF]
|
|
