|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online June 20, 2006
doi: 10.1242/10.1242/jcs.03053
Commentary |
Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, (C1428EHA) Buenos Aires, Argentina
* Author for correspondence (e-mail: ark{at}fbmc.fcen.uba.ar)
Accepted 17 May 2006
Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required to assure the complex orchestration of cellular processes within multicellular organisms. Mutations in cis-acting splicing elements or changes in the activity of constitutive or alternative splicing could have a profound regulatory proteins that compromise the accuracy of either impact on human pathogenesis, in particular in tumor development and progression. Mutations in splicing elements, for example, have been found in genes such as LKB1, KIT, CDH17, KLF6 and BRCA1, and changes in trans-acting regulators can affect the expression of genes such as Ron, RAC1 and CD44.
Key words: Splicing, Alternative splicing, Cancer, Signaling
This article has been cited by other articles:
|
|
 |
|
  K. M.-F. Sze, Y.-P. Ching, D.-Y. Jin, and I. O.-L. Ng Role of a Novel Splice Variant of Mitotic Arrest Deficient 1 (MAD1), MAD1{beta}, in Mitotic Checkpoint Control in Liver Cancer Cancer Res., November 15, 2008; 68(22): 9194 - 9201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. K. Kang, R. Schiff, L. Ko, T. Wang, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley Dual Roles for Coactivator Activator and its Counterbalancing Isoform Coactivator Modulator in Human Kidney Cell Tumorigenesis Cancer Res., October 1, 2008; 68(19): 7887 - 7896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Brown-Bryan, L. S. Leoh, V. Ganapathy, F. J. Pacheco, M. Mediavilla-Varela, M. Filippova, T. A. Linkhart, R. Gijsbers, Z. Debyser, and C. A. Casiano Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75 Mol. Cancer Res., August 1, 2008; 6(8): 1293 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cloutier, J. Toutant, L. Shkreta, S. Goekjian, T. Revil, and B. Chabot Antagonistic Effects of the SRp30c Protein and Cryptic 5 ' Splice Sites on the Alternative Splicing of the Apoptotic Regulator Bcl-x J. Biol. Chem., August 1, 2008; 283(31): 21315 - 21324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Fackenthal and L. A. Godley Aberrant RNA splicing and its functional consequences in cancer cells Dis. Model. Mech., July 1, 2008; 1(1): 37 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamaji, S. Yoshida, K. Ishikawa, A. Sengoku, K. Sato, A. Yoshida, R. Kuwahara, K. Ohuchida, E. Oki, H. Enaida, et al. TEM7 (PLXDC1) in Neovascular Endothelial Cells of Fibrovascular Membranes from Patients with Proliferative Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 3151 - 3157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. Pymar, F. M. Platt, J. M. Askham, E. E. Morrison, and M. A. Knowles Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms Hum. Mol. Genet., July 1, 2008; 17(13): 2006 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Thorsen, K. D. Sorensen, A. S. Brems-Eskildsen, C. Modin, M. Gaustadnes, A.-M. K. Hein, M. Kruhoffer, S. Laurberg, M. Borre, K. Wang, et al. Alternative Splicing in Colon, Bladder, and Prostate Cancer Identified by Exon Array Analysis Mol. Cell. Proteomics, July 1, 2008; 7(7): 1214 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sanchez, D. Bittencourt, K. Laud, J. Barbier, O. Delattre, D. Auboeuf, and M. Dutertre Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer PNAS, April 22, 2008; 105(16): 6004 - 6009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Haapasalo, M. Hilvo, K. Nordfors, H. Haapasalo, S. Parkkila, A. Hyrskyluoto, I. Rantala, A. Waheed, W. S. Sly, S. Pastorekova, et al. Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas Neuro-oncol, April 1, 2008; 10(2): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. O'Rourke and S. A. Ness Alternative RNA Splicing Produces Multiple Forms of c-Myb with Unique Transcriptional Activities Mol. Cell. Biol., March 15, 2008; 28(6): 2091 - 2101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Revil, J. Toutant, L. Shkreta, D. Garneau, P. Cloutier, and B. Chabot Protein Kinase C-Dependent Control of Bcl-x Alternative Splicing Mol. Cell. Biol., December 15, 2007; 27(24): 8431 - 8441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, S. Ryser, E. Dizin, D. Pils, M. Krainer, C. E. Jefford, F. Bertoni, R. Zeillinger, and I. Irminger-Finger Oncogenic BARD1 Isoforms Expressed in Gynecological Cancers Cancer Res., December 15, 2007; 67(24): 11876 - 11885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aartsma-Rus and G.-J. B. van Ommen Antisense-mediated exon skipping: A versatile tool with therapeutic and research applications RNA, October 1, 2007; 13(10): 1609 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Moroy and F. Heyd The impact of alternative splicing in vivo: Mouse models show the way RNA, August 1, 2007; 13(8): 1155 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Taylor, K. Yamasaki, K. A. Radek, A. D. Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2 J. Biol. Chem., June 22, 2007; 282(25): 18265 - 18275. [Abstract] [Full Text] [PDF]
|
|
