spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online May 24, 2006
doi: 10.1242/10.1242/jcs.03019

Journal of Cell Science 119, 2173-2183 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Appenzeller-Herzog, C.
Right arrow Articles by Hauri, H.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Appenzeller-Herzog, C.
Right arrow Articles by Hauri, H.-P.

Commentary

The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function

Christian Appenzeller-Herzog* and Hans-Peter Hauri{ddagger}

Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland

{ddagger} Author for correspondence (e-mail: Hans-Peter.Hauri{at}unibas.ch)

Accepted 18 April 2006

Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC), the marker of which is the lectin ERGIC-53. The dynamic nature and functional role of the ERGIC have been debated for quite some time. In the most popular current view, the ERGIC clusters are mobile transport complexes that deliver secretory cargo from ER-exit sites to the Golgi. Recent live-cell imaging data revealing the formation of anterograde carriers from stationary ERGIC-53-positive membranes, however, suggest a stable compartment model in which ER-derived cargo is first shuttled from ER-exit sites to stationary ERGIC clusters in a COPII-dependent step and subsequently to the Golgi in a second vesicular transport step. This model can better accommodate previous morphological and functional data on ER-to-Golgi traffic. Such a stationary ERGIC would be a major site of anterograde and retrograde sorting that is controlled by coat proteins, Rab and Arf GTPases, as well as tethering complexes, SNAREs and cytoskeletal networks. The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins.

Key words: ER-exit sites, ER-to-Golgi transport, ERGIC-53, Protein sorting, COPI, COPII, Tethering, Fusion




This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
X.-b. Chang, A. Mengos, Y.-x. Hou, L. Cui, T. J. Jensen, A. Aleksandrov, J. R. Riordan, and M. Gentzsch
Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator
J. Cell Sci., September 1, 2008; 121(17): 2814 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Sugeno, A. Takeda, T. Hasegawa, M. Kobayashi, A. Kikuchi, F. Mori, K. Wakabayashi, and Y. Itoyama
Serine 129 Phosphorylation of {alpha}-Synuclein Induces Unfolded Protein Response-mediated Cell Death
J. Biol. Chem., August 22, 2008; 283(34): 23179 - 23188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Chun, Z. Shapovalova, S. Y. Dejgaard, J. F. Presley, and P. Melancon
Characterization of Class I and II ADP-Ribosylation Factors (Arfs) in Live Cells: GDP-bound Class II Arfs Associate with the ER-Golgi Intermediate Compartment Independently of GBF1
Mol. Biol. Cell, August 1, 2008; 19(8): 3488 - 3500.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y. Guo, V. Punj, D. Sengupta, and A. D. Linstedt
Coat-Tether Interaction in Golgi Organization
Mol. Biol. Cell, July 1, 2008; 19(7): 2830 - 2843.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y. Wakana, S. Takai, K.-i. Nakajima, K. Tani, A. Yamamoto, P. Watson, D. J. Stephens, H.-P. Hauri, and M. Tagaya
Bap31 Is an Itinerant Protein That Moves between the Peripheral Endoplasmic Reticulum (ER) and a Juxtanuclear Compartment Related to ER-associated Degradation
Mol. Biol. Cell, May 1, 2008; 19(5): 1825 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. Mitrovic, H. Ben-Tekaya, E. Koegler, J. Gruenberg, and H.-P. Hauri
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi
Mol. Biol. Cell, May 1, 2008; 19(5): 1976 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
V. McEneaney, B. J. Harvey, and W. Thomas
Aldosterone Regulates Rapid Trafficking of Epithelial Sodium Channel Subunits in Renal Cortical Collecting Duct Cells via Protein Kinase D Activation
Mol. Endocrinol., April 1, 2008; 22(4): 881 - 892.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Farhan, V. Reiterer, A. Kriz, H.-P. Hauri, M. Pavelka, H. H. Sitte, and M. Freissmuth
Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif
J. Cell Sci., March 15, 2008; 121(6): 753 - 761.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
B. Nyfeler, V. Reiterer, M. W. Wendeler, E. Stefan, B. Zhang, S. W. Michnick, and H.-P. Hauri
Identification of ERGIC-53 as an intracellular transport receptor of {alpha}1-antitrypsin
J. Cell Biol., February 25, 2008; 180(4): 705 - 712.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Kawasaki, Y. Ichikawa, I. Matsuo, K. Totani, N. Matsumoto, Y. Ito, and K. Yamamoto
The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2
Blood, February 15, 2008; 111(4): 1972 - 1979.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. Manolea, A. Claude, J. Chun, J. Rosas, and P. Melancon
Distinct Functions for Arf Guanine Nucleotide Exchange Factors at the Golgi Complex: GBF1 and BIGs Are Required for Assembly and Maintenance of the Golgi Stack and trans-Golgi Network, Respectively
Mol. Biol. Cell, February 1, 2008; 19(2): 523 - 535.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Garstka, B. Borchert, M. Al-Balushi, P. Praveen, N. Kuhl, I. Majoul, R. Duden, and S. Springer
Peptide-receptive Major Histocompatibility Complex Class I Molecules Cycle between Endoplasmic Reticulum and cis-Golgi in Wild-type Lymphocytes
J. Biol. Chem., October 19, 2007; 282(42): 30680 - 30690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Vivithanaporn, L. L. Lash, W. Marszalec, and G. T. Swanson
Critical Roles for the M3 S2 Transduction Linker Domain in Kainate Receptor Assembly and Postassembly Trafficking
J. Neurosci., September 26, 2007; 27(39): 10423 - 10433.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. N. Ramanathan, D.-H. Chung, S. J. Plane, E. Sztul, Y.-k. Chu, M. C. Guttieri, M. McDowell, G. Ali, and C. B. Jonsson
Dynein-Dependent Transport of the Hantaan Virus Nucleocapsid Protein to the Endoplasmic Reticulum-Golgi Intermediate Compartment
J. Virol., August 15, 2007; 81(16): 8634 - 8647.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Wei, K. Hackmann, H. Xu, G. Germino, and F. Qian
Characterization of cis-Autoproteolysis of Polycystin-1, the Product of Human Polycystic Kidney Disease 1 Gene
J. Biol. Chem., July 27, 2007; 282(30): 21729 - 21737.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Saraste and B. Goud
Functional Symmetry of Endomembranes
Mol. Biol. Cell, April 1, 2007; 18(4): 1430 - 1436.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006