|
|
|
|
|
||
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online April 5, 2005
doi: 10.1242/10.1242/jcs.02335
Commentary |
Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
* Author for correspondence (e-mail: p.davino{at}gen.cam.ac.uk)
Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into independent daughter cells at the end of cell division. Although the metazoan mitotic spindle has been implicated in the placement and advancement of the cleavage furrow, the molecules responsible for these processes have remained elusive. Recent studies have provided insights into the role of different microtubule structures and associated proteins in cleavage furrow positioning and ingression together with the signalling events that regulate the dynamics of the equatorial cell cortex during cytokinesis. We try to unify these findings into a general model of cytokinesis in which both astral and central spindle microtubules have the ability to induce furrowing. We further propose that the evolutionarily conserved centralspindlin complex serves as a master controller of cell cleavage in Drosophila by promoting both furrow formation and ingression. The same mechanism might be conserved in other organisms.
Key words: Central spindle, Cleavage furrow, Contractile ring, Cytokinesis, Microtubules, Rho GTPases
This article has been cited by other articles:
|
|
 |
|
  R. Albertson, J. Cao, T.-s. Hsieh, and W. Sullivan Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle J. Cell Biol., October 20, 2008; 181(5): 777 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Silverman-Gavrila, K. G. Hales, and A. Wilde Anillin-mediated Targeting of Peanut to Pseudocleavage Furrows Is Regulated by the GTPase Ran Mol. Biol. Cell, September 1, 2008; 19(9): 3735 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Movshovich, V. Fridman, A. Gerson-Gurwitz, I. Shumacher, I. Gertsberg, A. Fich, M. A. Hoyt, B. Katz, and L. Gheber Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells J. Cell Sci., August 1, 2008; 121(15): 2529 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cao, R. Albertson, B. Riggs, C. M. Field, and W. Sullivan Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization J. Cell Biol., July 28, 2008; 182(2): 301 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Hu, M. Coughlin, C. M. Field, and T. J. Mitchison Cell polarization during monopolar cytokinesis J. Cell Biol., April 21, 2008; 181(2): 195 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. D'Avino, T. Takeda, L. Capalbo, W. Zhang, K. S. Lilley, E. D. Laue, and D. M. Glover Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site J. Cell Sci., April 15, 2008; 121(8): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gao, M. G. Giansanti, G. J. Buttrick, S. Ramasubramanyan, A. Auton, M. Gatti, and J. G. Wakefield Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis J. Cell Biol., February 6, 2008; 180(3): 521 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, H. G. Vikis, Y. Yi, M. Futamura, Y. Wang, and M. You Degradation of Lung Adenoma Susceptibility 1, a Major Candidate Mouse Lung Tumor Modifier, Is Required for Cell Cycle Progression Cancer Res., November 1, 2007; 67(21): 10207 - 10213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Margall-Ducos, S. Celton-Morizur, D. Couton, O. Bregerie, and C. Desdouets Liver tetraploidization is controlled by a new process of incomplete cytokinesis J. Cell Sci., October 15, 2007; 120(20): 3633 - 3639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Caldwell, R. A. Green, and K. B. Kaplan APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice J. Cell Biol., September 24, 2007; 178(7): 1109 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Jang, T. Rahman, V. S. Kober, J. Cesario, and K. S. McKim Misregulation of the Kinesin-like Protein Subito Induces Meiotic Spindle Formation in the Absence of Chromosomes and Centrosomes Genetics, September 1, 2007; 177(1): 267 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Riggs, B. Fasulo, A. Royou, S. Mische, J. Cao, T. S. Hays, and W. Sullivan The Concentration of Nuf, a Rab11 Effector, at the Microtubule-organizing Center Is Cell Cycle regulated, Dynein-dependent, and Coincides with Furrow Formation Mol. Biol. Cell, September 1, 2007; 18(9): 3313 - 3322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Villasante, J. P. Abad, and M. Mendez-Lago Centromeres were derived from telomeres during the evolution of the eukaryotic chromosome PNAS, June 19, 2007; 104(25): 10542 - 10547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. C. Verbrugghe and J. G. White Cortical centralspindlin and G{alpha} have parallel roles in furrow initiation in early C. elegans embryos J. Cell Sci., May 15, 2007; 120(10): 1772 - 1778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Siegrist and C. Q. Doe Microtubule-induced cortical cell polarity Genes & Dev., March 1, 2007; 21(5): 483 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Celton-Morizur, V. Racine, J.-B. Sibarita, and A. Paoletti Pom1 kinase links division plane position to cell polarity by regulating Mid1p cortical distribution J. Cell Sci., November 15, 2006; 119(22): 4710 - 4718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. D'Avino, M. S. Savoian, L. Capalbo, and D. M. Glover RacGAP50C is sufficient to signal cleavage furrow formation during cytokinesis J. Cell Sci., November 1, 2006; 119(21): 4402 - 4408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Delcros, C. Prigent, and R. Giet Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells J. Cell Sci., November 1, 2006; 119(21): 4431 - 4441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Shafikhani and J. Engel Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps PNAS, October 17, 2006; 103(42): 15605 - 15610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Chalamalasetty, S. Hummer, E. A. Nigg, and H. H. W. Sillje Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission J. Cell Sci., July 15, 2006; 119(14): 3008 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yoshida, K. Kono, D. M. Lowery, S. Bartolini, M. B. Yaffe, Y. Ohya, and D. Pellman Polo-Like Kinase Cdc5 Controls the Local Activation of Rho1 to Promote Cytokinesis Science, July 7, 2006; 313(5783): 108 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Gatt and D. M. Glover The Drosophila phosphatidylinositol transfer protein encoded by vibrator is essential to maintain cleavage-furrow ingression in cytokinesis J. Cell Sci., June 1, 2006; 119(11): 2225 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhu, E. Lau, R. Schwarzenbacher, E. Bossy-Wetzel, and W. Jiang Spatiotemporal control of spindle midzone formation by PRC1 in human cells PNAS, April 18, 2006; 103(16): 6196 - 6201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishimura and S. Yonemura Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis J. Cell Sci., January 1, 2006; 119(1): 104 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zavortink, N. Contreras, T. Addy, A. Bejsovec, and R. Saint Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster J. Cell Sci., November 15, 2005; 118(22): 5381 - 5392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Strickland, E. J. Donnelly, and D. R. Burgess Induction of Cytokinesis Is Independent of Precisely Regulated Microtubule Dynamics Mol. Biol. Cell, October 1, 2005; 16(10): 4485 - 4494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Jang, T. Rahman, and K. S. McKim The Kinesinlike Protein Subito Contributes to Central Spindle Assembly and Organization of the Meiotic Spindle in Drosophila Oocytes Mol. Biol. Cell, October 1, 2005; 16(10): 4684 - 4694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. O. Dean, S. L. Rogers, N. Stuurman, R. D. Vale, and J. A. Spudich Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis PNAS, September 20, 2005; 102(38): 13473 - 13478. [Abstract] [Full Text] [PDF]
|
|
