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First published online 15 February 2005
doi: 10.1242/jcs.01678

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Loss of 10ß1 integrin expression leads to moderate dysfunction of growth plate chondrocytes

¹ Department of Experimental Pathology, Lund University Hospital, Box 117, 22185 Lund, Sweden
² Cartela AB, BioMedical Center I12, Sölvegatan 19, 22184 Lund, Sweden
³ Max Planck Institute of Biochemistry, Department for Molecular Medicine, Am Klopferspitz 18, 82152 Martinsried, Germany
⁴ ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, PO Box 54, CH-3010 Bern, Switzerland

^* Author for correspondence (e-mail: faessler{at}biochem.mpg.de)

Accepted 8 December 2004

Integrin 10ß1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the 10 integrin during development, we generated mice carrying a constitutive deletion of the 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin 10ß1 plays a specific role in growth plate morphogenesis and function.

Key words: Integrin, Knockout, Cartilage, Growth plate, Proliferation

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