spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 16, 2005
doi: 10.1242/10.1242/jcs.02532

Journal of Cell Science 118, 3585-3594 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woodward, W. A.
Right arrow Articles by Rosen, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woodward, W. A.
Right arrow Articles by Rosen, J. M.

Commentary

On mammary stem cells

Wendy A. Woodward1,*, Mercy S. Chen2,*, Fariba Behbod2 and Jeffrey M. Rosen2,{ddagger}

1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-3498, USA
2 Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Place, M638a DeBakey, Houston, TX 77030, USA

{ddagger} Author for correspondence (e-mail: jrosen{at}bcm.edu)

Mammary gland stem cells are a quiescent and self-renewing population within the mammary gland that are capable of giving rise to the differentiated ductal, alveolar and myoepithelial cells. To identify mammary gland stem cells, several investigators have employed a variety of methods including: non-adherent mammosphere cultures; 5-bromo-2-deoxy-uridine (BrdU) label-retention studies; cell-surface markers, such as Sca1 and CD49f; and Hoechst dye efflux. These methods have helped identify and further characterize signal transduction pathways such as the Notch, Wnt and Hedgehog pathways that may be important for the self-renewal and fate determination of mammary gland stem cells. Stem cells within the mammary gland have been proposed to underpin many types of breast cancer. A better understanding of the signal transduction pathways and the molecules that are responsible for the self-renewal and survival of these cells will be essential in the design of more effective therapies aimed at the eradication of both cancer-initiating cells and breast cancer stem cells.

Key words: SP, Sca1, LRC, Stem cells, {alpha}6-integrin, ER




This article has been cited by other articles:


Home page
 Stem CellsHome page
N. Li, S. Singh, P. Cherukuri, H. Li, Z. Yuan, L. W. Ellisen, B. Wang, D. Robbins, and J. DiRenzo
Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells
Stem Cells, May 1, 2008; 26(5): 1253 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. S.L. Cheng, A. C. Culhane, M. W.Y. Chan, C. R. Venkataramu, M. Ehrich, A. Nasir, B. A.T. Rodriguez, J. Liu, P. S. Yan, J. Quackenbush, et al.
Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like Methylome
Cancer Res., March 15, 2008; 68(6): 1786 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Y. Lee, M. L. Palmer, P. J. Maniak, S. H. Jang, P. D. Ryu, and S. M. O'Grady
P2Y receptor regulation of sodium transport in human mammary epithelial cells
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1472 - C1480.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. Mimeault and S. K. Batra
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
Ann. Onc., October 1, 2007; 18(10): 1605 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
V. Bolos, J. Grego-Bessa, and J. L. de la Pompa
Notch Signaling in Development and Cancer
Endocr. Rev., May 1, 2007; 28(3): 339 - 363.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
R. Villadsen, A. J. Fridriksdottir, L. Ronnov-Jessen, T. Gudjonsson, F. Rank, M. A. LaBarge, M. J. Bissell, and O. W. Petersen
Evidence for a stem cell hierarchy in the adult human breast
J. Cell Biol., April 9, 2007; 177(1): 87 - 101.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. S. Chen, W. A. Woodward, F. Behbod, S. Peddibhotla, M. P. Alfaro, T. A. Buchholz, and J. M. Rosen
Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
J. Cell Sci., February 1, 2007; 120(3): 468 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. A. Woodward, M. S. Chen, F. Behbod, M. P. Alfaro, T. A. Buchholz, and J. M. Rosen
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
PNAS, January 9, 2007; 104(2): 618 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C.E. Gargett
Uterine stem cells: What is the evidence?
Hum. Reprod. Update, January 1, 2007; 13(1): 87 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
S. DE ASSIS and L. HILAKIVI-CLARKE
Timing of Dietary Estrogenic Exposures and Breast Cancer Risk
Ann. N.Y. Acad. Sci., November 1, 2006; 1089(1): 14 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Mimeault and S. K. Batra
Concise Review: Recent Advances on the Significance of Stem Cells in Tissue Regeneration and Cancer Therapies
Stem Cells, November 1, 2006; 24(11): 2319 - 2345.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. T. Jordan, M. L. Guzman, and M. Noble
Cancer stem cells.
N. Engl. J. Med., September 21, 2006; 355(12): 1253 - 1261.
[Full Text] [PDF]


© The Company of Biologists Ltd 2005