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First published online 21 June 2005
doi: 10.1242/jcs.02430

Journal of Cell Science 118, 3027-3035 (2005)
Published by The Company of Biologists 2005
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Research Article

Germ cells and fatty acids induce translocation of CD36 scavenger receptor to the plasma membrane of Sertoli cells

Isabelle Gillot1, Chantal Jehl-Pietri1, Pierre Gounon2, Serge Luquet3, Minoo Rassoulzadegan1, Paul Grimaldi1 and Frédérique Vidal1,*

1 INSERM UMR 636, Université de Nice-Sophia Antipolis, Faculty of Sciences – Parc Valrose, 06108 Nice Cedex 2, France
2 CCMA, Université de Nice-Sophia Antipolis, Faculty of Sciences – Parc Valrose, 06108 Nice Cedex 2, France
3 Departments of Biochemistry and Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle, WA 98195, USA

* Author for correspondence (e-mail: vidal{at}unice.fr)

Accepted 7 April 2005

The CD36 scavenger receptor is involved in the uptake and transport of fatty acids, as well as the phagocytosis process in macrophages. We show here that the CD36 protein is expressed by Sertoli cells in the seminiferous epithelium, mainly during the stages where phagocytosis takes place. Using a Sertoli-derived cell line, we show that addition of germ cells and residual bodies triggers a re-localization of CD36 from the cytoplasm to the plasma membrane of the cells, while latex beads do not. Moreover, Sertoli cell phagocytosis of germ cells, but not of latex beads, is reduced by the presence of fatty acids in the culture medium. In the testis, CD36 plays a key role in both phagocytosis and lipid recycling, for constant production of mature spermatozoa.

Key words: CD36, Spermatogenesis, Phagocytosis, Sertoli cells, Germ cells




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© The Company of Biologists Ltd 2005