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First published online October 27, 2004
doi: 10.1242/10.1242/jcs.01540

Journal of Cell Science 117, 5479-5487 (2004)
Published by The Company of Biologists 2004
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Commentary

The AMP-activated protein kinase pathway – new players upstream and downstream

D. Grahame Hardie

Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK

(e-mail: d.g.hardie{at}dundee.ac.uk)

The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that inhibits ATP production or increases ATP consumption, this is amplified by adenylate kinase into a much larger increase in the AMP:ATP ratio. AMP activates the system by binding to two tandem domains on the {gamma} subunits of AMPK, and this is antagonized by high concentrations of ATP. AMP binding causes activation by a sensitive mechanism involving phosphorylation of AMPK by the tumour suppressor LKB1. Once activated, AMPK switches on catabolic pathways that generate ATP while switching off ATP-consuming processes. As well as acting at the level of the individual cell, the system also regulates food intake and energy expenditure at the whole body level, in particular by mediating the effects of hormones and cytokines such as leptin, adiponectin and ghrelin. A particularly interesting downstream target recently identified is TSC2 (tuberin). The LKB1->AMPK->TSC2 pathway negatively regulates the target of rapamycin (TOR), and this appears to be responsible for limiting protein synthesis and cell growth, and protecting against apoptosis, during cellular stresses such as glucose starvation.

Key words: AMP-activated protein kinase, LKB1, TSC2




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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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S.-P. Hong and M. Carlson
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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Exp Physiol, January 1, 2007; 92(1): 207 - 217.
[Abstract] [Full Text] [PDF]

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J. Am. Soc. Nephrol., December 1, 2006; 17(12): 3281 - 3292.
[Abstract] [Full Text] [PDF]

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Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2875 - H2883.
[Abstract] [Full Text] [PDF]

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J. Biol. Chem., November 17, 2006; 281(46): 34870 - 34879.
[Abstract] [Full Text] [PDF]

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