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doi: 10.1242/10.1242/jcs.00229
Hypothesis |
Departments of Cell Biology and Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
* Author for correspondence (e-mail: annesj01{at}med.nyu.edu)
TGFß is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, `TGFß activators,' release TGFß from its latent state. The unusual temporal discontinuity of TGFß synthesis and action and the panoply of TGFß effects contribute to the interest in TGF-ß. However, the logical connections between TGFß synthesis, storage and action are obscure. We consider the latent TGFß complex as an extracellular sensor in which the TGFß propeptide functions as the detector, latent-TGFß-binding protein (LTBP) functions as the localizer, and TGF-ß functions as the effector. Such a view provides a logical continuity for various aspects of TGFß biology and allows us to appreciate TGFß biology from a new perspective.
Key words: Transforming growth factor-ß, Activation, Sensor
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