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First published online 20 May 2003
doi: 10.1242/jcs.00475

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3ß1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis

¹ Cancer Research UK, Cell Adhesion and Disease Laboratory, Richard Dimbleby Department of Cancer Research, St Thomas' Hospital, London SE1 7EH, UK
² 2nd Floor, South Wing, Block 7, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK

^* Author for correspondence (e-mail: kairbaan.hodivala-dilke{at}cancer.org.uk)

Accepted 10 March 2003

3ß1-integrin is abundantly expressed in the epidermis, and in mice, ablation of the 3 gene results in embryonic defects and perinatal lethality. To determine the role of 3-integrin in adult skin development, we grafted skin from newborn 3-integrin-deficient mice on to ICRF nu/nu recipients. We report that adult 3-integrin-deficient skin has severe abnormalities restricted to hair follicle morphology, which include stunted hair follicle growth, increased hair follicle fragility, aberrant pigment accumulation and formation of hair follicle clusters. These abnormalities are caused by a combination of defects in: (1) keratinocyte cytoskeletal organisation, (2) outer root sheath architecture and (3) integrity of the lamina densa. Our results indicate that 3ß1 is not essential for adult interfollicular epidermal differentiation, but it is required to direct several processes important in hair follicle maintenance and morphogenesis.

Key words: 3-integrin, F-actin, Hair follicle abnormalities

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