QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/jcs.00183

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bredt, D. S. Search for Related Content PubMed PubMed Citation Articles by Bredt, D. S.

Nitric oxide signaling specificity — the heart of the problem

Department of Physiology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143-0444, USA

(e-mail: bredt{at}phy.ucsf.edu)

Nitric oxide (NO) is a gaseous free radical that functions as an endogenous mediator in numerous tissues. Because NO is both reactive and highly diffusible, its formation must be tightly regulated to control its synthesis and to specify its signaling. Indeed, molecular studies of the NO synthase (NOS) family of enzymes have elaborated a variety of mechanisms, including protein interactions, lipid modifications and protein phosphorylation cascades that spatially and temporally control NO biosynthesis. These mechanisms determine both the upstream cellular signals that stimulate NO formation and the downstream molecular targets for NO. Understanding these cellular pathways that control NOS will help us to elucidate the functional roles of NO and provide novel strategies to treat diseases associated with NO abnormalities.

Key words: Nitric oxide, Heart, Protein targeting, PDZ domain

Related articles in JCS:

Nitric oxide signalling compartments

JCS 2003 116: 101. [Full Text]  

This article has been cited by other articles:

				J. Zhang, Z. Xie, Y. Dong, S. Wang, C. Liu, and M.-H. Zou Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells J. Biol. Chem., October 10, 2008; 283(41): 27452 - 27461. [Abstract] [Full Text] [PDF]

				S. A. Korneev, E. I. Korneeva, M. A. Lagarkova, S. L. Kiselev, G. Critchley, and M. O'Shea Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells RNA, October 1, 2008; 14(10): 2030 - 2037. [Abstract] [Full Text] [PDF]

				M. William, E. J. Hamilton, A. Garcia, H. Bundgaard, K. K. M. Chia, G. A. Figtree, and H. H. Rasmussen Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1067 - C1073. [Abstract] [Full Text] [PDF]

				A. Marechal, T. A. Mattioli, D. J. Stuehr, and J. Santolini Activation of Peroxynitrite by Inducible Nitric-oxide Synthase: A DIRECT SOURCE OF NITRATIVE STRESS J. Biol. Chem., May 11, 2007; 282(19): 14101 - 14112. [Abstract] [Full Text] [PDF]

				G. A. Rameau, D. S. Tukey, E. D. Garcin-Hosfield, R. F. Titcombe, C. Misra, L. Khatri, E. D. Getzoff, and E. B. Ziff Biphasic Coupling of Neuronal Nitric Oxide Synthase Phosphorylation to the NMDA Receptor Regulates AMPA Receptor Trafficking and Neuronal Cell Death J. Neurosci., March 28, 2007; 27(13): 3445 - 3455. [Abstract] [Full Text] [PDF]

				R. M. LoPachin and D. S. Barber Synaptic Cysteine Sulfhydryl Groups as Targets of Electrophilic Neurotoxicants Toxicol. Sci., December 1, 2006; 94(2): 240 - 255. [Abstract] [Full Text] [PDF]

				Y. Dong and L. P. Thompson Differential Expression of Endothelial Nitric Oxide Synthase in Coronary and Cardiac Tissue in Hypoxic Fetal Guinea Pig Hearts Reproductive Sciences, October 1, 2006; 13(7): 483 - 490. [Abstract] [PDF]

				I. Navarro-Lerida, M. M. Corvi, A. A. Barrientos, F. Gavilanes, L. G. Berthiaume, and I. Rodriguez-Crespo Palmitoylation of Inducible Nitric-oxide Synthase at Cys-3 Is Required for Proper Intracellular Traffic and Nitric Oxide Synthesis J. Biol. Chem., December 31, 2004; 279(53): 55682 - 55689. [Abstract] [Full Text] [PDF]

				S. De Seranno, C. Estrella, A. Loyens, A. Cornea, S. R. Ojeda, J.-C. Beauvillain, and V. Prevot Vascular Endothelial Cells Promote Acute Plasticity in Ependymoglial Cells of the Neuroendocrine Brain J. Neurosci., November 17, 2004; 24(46): 10353 - 10363. [Abstract] [Full Text] [PDF]

				A. Martinez-Ruiz and S. Lamas S-nitrosylation: a potential new paradigm in signal transduction Cardiovasc Res, April 1, 2004; 62(1): 43 - 52. [Abstract] [Full Text] [PDF]

				S. M. Lowson Nitric Oxide Signaling and Clinical Alternatives to Nitric Oxide Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 239 - 252. [Abstract] [PDF]