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doi: 10.1242/10.1242/jcs.00218

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Journal of Cell Science 115, 4721-4726 (2002)
doi: 10.1242/jcs.00218

Commentary

The Ena/VASP enigma

Matthias Krause, James E. Bear, Joseph J. Loureiro and Frank B. Gertler*

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA

* Author for correspondence (e-mail: fgertler{at}mit.edu)

Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as `anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.

Key words: Ena/VASP, VASP, Mena, Capping protein, Actin, Cell motility, Lamellipodia


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