QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/jcs.00094

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sun, C.-X. Articles by Gutmann, D. H. Search for Related Content PubMed PubMed Citation Articles by Sun, C.-X. Articles by Gutmann, D. H.

Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation

Chun-Xiao Sun^*, Victoria A. Robb^* and David H. Gutmann

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA

Author for correspondence (e-mail: gutmannd{at}neuro.wustl.edu)

Members of the Protein 4.1 superfamily have highly conserved FERM domains that link cell surface glycoproteins to the actin cytoskeleton. Within this large and constantly expanding superfamily, at least five subgroups have been proposed. Two of these subgroups, the ERM and prototypic Protein 4.1 molecules, include proteins that function as tumor suppressors. The ERM subgroup member merlin/schwannomin is inactivated in the tumor-predisposition syndrome neurofibromatosis 2 (NF2), and the prototypic 4.1 subgroup member, Protein 4.1B, has been implicated in the molecular pathogenesis of breast, lung and brain cancers. This review focuses on what is known of mechanisms of action and critical protein interactions that may mediate the unique growth inhibitory signals of these two Protein 4.1 tumor suppressors. On the basis of insights derived from studying the NF2 tumor suppressor, we propose a model for merlin growth regulation in which CD44 links growth signals from plasma membrane to the nucleus by interacting with ERM proteins and merlin.

Key words: Merlin, DAL-1, Tumor suppressor, Schwannomin

Related articles in JCS:

Tumour suppression by merlin and 4.1 proteins

JCS 2002 115: 2102. [Full Text]  

This article has been cited by other articles:

				T. Yokoyama, H. Osada, H. Murakami, Y. Tatematsu, T. Taniguchi, Y. Kondo, Y. Yatabe, Y. Hasegawa, K. Shimokata, Y. Horio, et al. YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation Carcinogenesis, November 1, 2008; 29(11): 2139 - 2146. [Abstract] [Full Text] [PDF]

				M. Hirano, S. Hashimoto, S. Yonemura, H. Sabe, and S. Aizawa EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition J. Cell Biol., September 22, 2008; 182(6): 1217 - 1230. [Abstract] [Full Text] [PDF]

				S. Y. Wong, H. Haack, J. L. Kissil, M. Barry, R. T. Bronson, S. S. Shen, C. A. Whittaker, D. Crowley, and R. O. Hynes Protein 4.1B suppresses prostate cancer progression and metastasis PNAS, July 31, 2007; 104(31): 12784 - 12789. [Abstract] [Full Text] [PDF]

				S.-i. Terawaki, K. Kitano, and T. Hakoshima Structural Basis for Type II Membrane Protein Binding by ERM Proteins Revealed by the Radixin-neutral Endopeptidase 24.11 (NEP) Complex J. Biol. Chem., July 6, 2007; 282(27): 19854 - 19862. [Abstract] [Full Text] [PDF]

				M. A. Gerber, S. M. Bahr, and D. H. Gutmann Protein 4.1B/Differentially Expressed in Adenocarcinoma of the Lung-1 Functions as a Growth Suppressor in Meningioma Cells by Activating Rac1-Dependent c-Jun-NH2-kinase Signaling. Cancer Res., May 15, 2006; 66(10): 5295 - 5303. [Abstract] [Full Text] [PDF]

				D. R. Scoles, W. H. Yong, Y. Qin, K. Wawrowsky, and S. M. Pulst Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c) Hum. Mol. Genet., April 1, 2006; 15(7): 1059 - 1070. [Abstract] [Full Text] [PDF]

				C. Yi, J. H. McCarty, S. A. Troutman, M. S. Eckman, R. T. Bronson, and J. L. Kissil Loss of the Putative Tumor Suppressor Band 4.1B/Dal1 Gene Is Dispensable for Normal Development and Does Not Predispose to Cancer Mol. Cell. Biol., November 15, 2005; 25(22): 10052 - 10059. [Abstract] [Full Text] [PDF]

				T. Fukuhara, K. Shimizu, T. Kawakatsu, T. Fukuyama, Y. Minami, T. Honda, T. Hoshino, T. Yamada, H. Ogita, M. Okada, et al. Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG J. Cell Biol., August 2, 2004; 166(3): 393 - 405. [Abstract] [Full Text] [PDF]

				J. Y. Lee, H. Kim, C. H. Ryu, J. Y. Kim, B. H. Choi, Y. Lim, P.-W. Huh, Y.-H. Kim, K.-H. Lee, T.-Y. Jun, et al. Merlin, a Tumor Suppressor, Interacts with Transactivation-responsive RNA-binding Protein and Inhibits Its Oncogenic Activity J. Biol. Chem., July 16, 2004; 279(29): 30265 - 30273. [Abstract] [Full Text] [PDF]

				M. F. James, R. L. Beauchamp, N. Manchanda, A. Kazlauskas, and V. Ramesh A NHERF binding site links the {beta}PDGFR to the cytoskeleton and regulates cell spreading and migration J. Cell Sci., June 15, 2004; 117(14): 2951 - 2961. [Abstract] [Full Text] [PDF]

				H. Kim, N.-J. Kwak, J. Y. Lee, B. H. Choi, Y. Lim, Y. J. Ko, Y.-H. Kim, P.-W. Huh, K.-H. Lee, H. K. Rha, et al. Merlin Neutralizes the Inhibitory Effect of Mdm2 on p53 J. Biol. Chem., February 27, 2004; 279(9): 7812 - 7818. [Abstract] [Full Text] [PDF]

				J. Sanceau, S. Truchet, and B. Bauvois Matrix Metalloproteinase-9 Silencing by RNA Interference Triggers the Migratory-adhesive Switch in Ewing's Sarcoma Cells J. Biol. Chem., September 19, 2003; 278(38): 36537 - 36546. [Abstract] [Full Text] [PDF]

				D. Lallemand, M. Curto, I. Saotome, M. Giovannini, and A. I. McClatchey NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions Genes & Dev., May 1, 2003; 17(9): 1090 - 1100. [Abstract] [Full Text] [PDF]

				J. T. Parsons Focal adhesion kinase: the first ten years J. Cell Sci., April 15, 2003; 116(8): 1409 - 1416. [Abstract] [Full Text] [PDF]