|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 114, Issue 5 845-851, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
JW Yewdell, U Schubert and JR Bennink
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA.
CD8(+) T cells are a critical element of vertebrate immune responses to viruses and other intracellular parasites. They roam the body, monitoring cells for the presence of foreign peptides associated with MHC class I molecules of the major histocompatibility complex (MHC). Although it is clear that most of these peptides are generated through the action of proteasomes, the nature of the substrates degraded by proteasomes is an open question. Recent findings indicate that the major pool of substrates consists of a heterogeneous subset of proteins that are degraded within minutes of their synthesis. Evidence suggests that the fraction of newly synthesized proteins targeted for destruction is remarkably high - 30% or more, depending on cell type - possibly because they are defective in some way and cannot reach their intended conformation or location cellular in a time frame deemed appropriate by cells.
This article has been cited by other articles:
|
|
 |
|
  J. Tellam, C. Smith, M. Rist, N. Webb, L. Cooper, T. Vuocolo, G. Connolly, D. C. Tscharke, M. P. Devoy, and R. Khanna From the Cover: Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition PNAS, July 8, 2008; 105(27): 9319 - 9324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tellam, M. H. Fogg, M. Rist, G. Connolly, D. Tscharke, N. Webb, L. Heslop, F. Wang, and R. Khanna Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes J. Exp. Med., March 19, 2007; 204(3): 525 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O. Weinzierl, C. Lemmel, O. Schoor, M. Muller, T. Kruger, D. Wernet, J. Hennenlotter, A. Stenzl, K. Klingel, H.-G. Rammensee, et al. Distorted Relation between mRNA Copy Number and Corresponding Major Histocompatibility Complex Ligand Density on the Cell Surface Mol. Cell. Proteomics, January 1, 2007; 6(1): 102 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-B. Qian, E. Reits, J. Neefjes, J. M. Deslich, J. R. Bennink, and J. W. Yewdell Tight Linkage between Translation and MHC Class I Peptide Ligand Generation Implies Specialized Antigen Processing for Defective Ribosomal Products J. Immunol., July 1, 2006; 177(1): 227 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Milner, E. Barnea, I. Beer, and A. Admon The Turnover Kinetics of Major Histocompatibility Complex Peptides of Human Cancer Cells Mol. Cell. Proteomics, February 1, 2006; 5(2): 357 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-B. Qian, M. F. Princiotta, J. R. Bennink, and J. W. Yewdell Characterization of Rapidly Degraded Polypeptides in Mammalian Cells Reveals a Novel Layer of Nascent Protein Quality Control J. Biol. Chem., January 6, 2006; 281(1): 392 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Caron, R. Charbonneau, G. Huppe, S. Brochu, and C. Perreault The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome Int. Immunol., December 1, 2005; 17(12): 1583 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ceppi, M. G. M. de Bruin, T. Seuberlich, C. Balmelli, S. Pascolo, N. Ruggli, D. Wienhold, J. D. Tratschin, K. C. McCullough, and A. Summerfield Identification of classical swine fever virus protein E2 as a target for cytotoxic T cells by using mRNA-transfected antigen-presenting cells J. Gen. Virol., September 1, 2005; 86(9): 2525 - 2534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Herter, P. Osterloh, N. Hilf, G. Rechtsteiner, J. Hohfeld, H.-G. Rammensee, and H. Schild Dendritic Cell Aggresome-Like-Induced Structure Formation and Delayed Antigen Presentation Coincide in Influenza Virus-Infected Dendritic Cells J. Immunol., July 15, 2005; 175(2): 891 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lelouard, V. Ferrand, D. Marguet, J. Bania, V. Camosseto, A. David, E. Gatti, and P. Pierre Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins J. Cell Biol., March 1, 2004; 164(5): 667 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Voo, T. Fu, H. Y. Wang, J. Tellam, H. E. Heslop, M. K. Brenner, C. M. Rooney, and R.-F. Wang Evidence for the Presentation of Major Histocompatibility Complex Class I-restricted Epstein-Barr Virus Nuclear Antigen 1 Peptides to CD8+ T Lymphocytes J. Exp. Med., February 17, 2004; 199(4): 459 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yin, B. Manoury, and R. Fahraeus Self-Inhibition of Synthesis and Antigen Presentation by Epstein-Barr Virus-Encoded EBNA1 Science, September 5, 2003; 301(5638): 1371 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Admon, E. Barnea, and T. Ziv Tumor Antigens and Proteomics from the Point of View of the Major Histocompatibility Complex Peptides Mol. Cell. Proteomics, June 1, 2003; 2(6): 388 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Glickman and A. Ciechanover The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction Physiol Rev, April 1, 2002; 82(2): 373 - 428. [Abstract] [Full Text] [PDF]
|
|
