spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Postberg, J.
Right arrow Articles by Lipps, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Postberg, J.
Right arrow Articles by Lipps, H. J.

Journal of Cell Science, Vol 114, Issue 10 1861-1866, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Association of the telomere-telomere-binding protein complex of hypotrichous ciliates with the nuclear matrix and dissociation during replication

J Postberg, SA Juranek, S Feiler, H Kortwig, F Jonsson and HJ Lipps
Institute for Cell Biology, University Witten/Herdecke, Stockumer Str. 10, D-58448 Witten, Germany. lipps@uni-wh.de

Telomeric interactions with the nuclear matrix have been described in a variety of eukaryotic cells and seem to be essential for specific nuclear localization. Macronuclear DNA of hypotrichous ciliates occurs in small gene-sized DNA molecules, each being terminated by telomeres. Each macronucleus contains over 10(8 )individual DNA molecules. Owing to the high number of telomeres present in this nucleus it provides an excellent model to study telomere behaviour throughout the cell cycle. In this study we provide experimental evidence that the telomere-telomere-binding protein (TEBP) complex specifically interacts with components of the nuclear matrix in vivo. In the course of replication the specific interaction of the TEBP with components of the nuclear matrix is resolved and an attachment of the telomeres to the matrix no longer occurs.


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
J. Postberg, O. Alexandrova, T. Cremer, and H. J. Lipps
Exploiting nuclear duality of ciliates to analyse topological requirements for DNA replication and transcription
J. Cell Sci., September 1, 2005; 118(17): 3973 - 3983.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Mollenbeck, J. Postberg, K. Paeschke, M. Rossbach, F. Jonsson, and H. J. Lipps
The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleus
J. Cell Sci., May 1, 2003; 116(9): 1757 - 1761.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Schaffitzel, I. Berger, J. Postberg, J. Hanes, H. J. Lipps, and A. Pluckthun
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
PNAS, June 28, 2001; (2001) 141229498.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Schaffitzel, I. Berger, J. Postberg, J. Hanes, H. J. Lipps, and A. Pluckthun
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
PNAS, July 17, 2001; 98(15): 8572 - 8577.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001