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Journal of Cell Science, Vol 113, Issue 20 3673-3678, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

XD Ren, WB Kiosses, DJ Sieg, CA Otey, DD Schlaepfer and MA Schwartz
Departments of Vascular Biology and Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion number and decreased cell migration, functions that are regulated by the small GTPase Rho. We now report that fibroblasts from FAK-/- mice failed to transiently inhibit Rho activity when plated on fibronectin. Re-expression of FAK restored normal Rho regulation. Turnover of focal adhesions correlated inversely with Rho activity. The presence or absence of FAK was mimicked by inhibiting or activating Rho, respectively. These data suggest that loss of FAK resulting in constitutive activation of Rho and inhibition of focal adhesion turnover can account for deficiencies in cell migration and embryonic lethality of the FAK knockout.


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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Clin. Cancer Res., February 1, 2005; 11(3): 1050 - 1058.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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J. Cell Sci., July 15, 2004; 117(16): 3511 - 3518.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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J. Cell Sci., July 1, 2004; 117(15): 3389 - 3403.
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Home page
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[Abstract] [Full Text] [PDF]

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Mol. Biol. Cell, June 1, 2004; 15(6): 2943 - 2953.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., March 26, 2004; 279(13): 12001 - 12004.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., March 5, 2004; 279(10): 9565 - 9576.
[Abstract] [Full Text] [PDF]

Home page
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Science, February 6, 2004; 303(5659): 836 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
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J. Cell Sci., January 1, 2004; 117(1): 41 - 52.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., November 28, 2003; 278(48): 47946 - 47959.
[Abstract] [Full Text] [PDF]

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