|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 112, Issue 21 3649-3656, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
S Smith and T de Lange
Laboratory for Cell Biology and Genetics, The Rockefeller University, New York NY 10021, USA.
Tankyrase is a human poly(ADP-ribose) polymerase that was initially identified through its interaction with the telomeric protein TRF1, a negative regulator of telomere length. In vitro poly(ADP-ribosyl)ation by tankyrase inhibits TRF1 binding to telomeric DNA suggesting a role for tankyrase in telomere function. We previously demonstrated that tankyrase co-localizes with TRF1 at the ends of human chromosomes in metaphase. Here we show that tankyrase localizes to additional subcellular sites in a cell cycle dependent manner. In interphase, tankyrase co-localized with TRF1 to telomeres, but in addition was found to reside at nuclear pore complexes, as evidenced by indirect immunofluorescence, subcellular fractionation and immunoelectron microscopy. At mitosis, concomitant with nuclear envelope breakdown and nuclear pore complex disassembly, tankyrase was found to relocate around the pericentriolar matrix of mitotic centrosomes. This complex staining pattern along with the observation that tankyrase did not contain a nuclear localization signal suggested that its telomeric localization might be regulated, perhaps by TRF1. Indeed, localization of exogenously-expressed tankyrase to telomeres was dependent upon co-transfection with TRF1. These data indicate that the subcellular localization of tankyrase can be regulated by both the cell cycle and TRF1.
This article has been cited by other articles:
|
|
 |
|
  Q. Li, N. Zhang, D. Zhang, Y. Wang, T. Lin, Y. Wang, H. Zhou, Z. Ye, F. Zhang, S.-C. Lin, et al. Determinants That Control the Distinct Subcellular Localization of p38{alpha}-PRAK and p38{beta}-PRAK Complexes J. Biol. Chem., April 18, 2008; 283(16): 11014 - 11023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Donigian and T. de Lange The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex J. Biol. Chem., August 3, 2007; 282(31): 22662 - 22667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. O. Hassa, S. S. Haenni, M. Elser, and M. O. Hottiger Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going? Microbiol. Mol. Biol. Rev., September 1, 2006; 70(3): 789 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. E. Chou, H. T. Chou, and S.-C. Lee CDK-dependent Activation of Poly(ADP-ribose) Polymerase Member 10 (PARP10) J. Biol. Chem., June 2, 2006; 281(22): 15201 - 15207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomez, J. Wu, V. Schreiber, J. Dunlap, F. Dantzer, Y. Wang, and Y. Liu PARP1 Is a TRF2-associated Poly(ADP-Ribose)Polymerase and Protects Eroded Telomeres Mol. Biol. Cell, April 1, 2006; 17(4): 1686 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Hsiao, M. F. Poitras, B. D. Cook, Y. Liu, and S. Smith Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping. Mol. Cell. Biol., March 1, 2006; 26(6): 2044 - 2054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Kim, T. Zhang, and W. L. Kraus Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal Genes & Dev., September 1, 2005; 19(17): 1951 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Deng, C. Atanasiu, K. Zhao, R. Marmorstein, J. I. Sbodio, N.-W. Chi, and P. M. Lieberman Inhibition of Epstein-Barr Virus OriP Function by Tankyrase, a Telomere-Associated Poly-ADP Ribose Polymerase That Binds and Modifies EBNA1 J. Virol., April 15, 2005; 79(8): 4640 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Okano, L. Lan, A. E. Tomkinson, and A. Yasui Translocation of XRCC1 and DNA ligase III{alpha} from centrosomes to chromosomes in response to DNA damage in mitotic human cells Nucleic Acids Res., January 14, 2005; 33(1): 422 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Xu and E. H. Blackburn Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules J. Cell Biol., December 6, 2004; 167(5): 819 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. De Rycker and C. M. Price Tankyrase Polymerization Is Controlled by Its Sterile Alpha Motif and Poly(ADP-Ribose) Polymerase Domains Mol. Cell. Biol., November 15, 2004; 24(22): 9802 - 9812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ertsey, C. J. Chapin, J. A. Kitterman, and L. M. Scavo Ontogeny of Poly(ADP-Ribose) Polymerase-1 in Lung and Developmental Implications Am. J. Respir. Cell Mol. Biol., June 1, 2004; 30(6): 853 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Dynek and S. Smith Resolution of Sister Telomere Association Is Required for Progression Through Mitosis Science, April 2, 2004; 304(5667): 97 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Seimiya, Y. Muramatsu, S. Smith, and T. Tsuruo Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation Mol. Cell. Biol., March 1, 2004; 24(5): 1944 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rouleau, R. A. Aubin, and G. G. Poirier Poly(ADP-ribosyl)ated chromatin domains: access granted J. Cell Sci., February 22, 2004; 117(6): 815 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dantzer, M.-J. Giraud-Panis, I. Jaco, J.-C. Ame, I. Schultz, M. Blasco, C.-E. Koering, E. Gilson, J. Menissier-de Murcia, G. de Murcia, et al. Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2 Mol. Cell. Biol., February 15, 2004; 24(4): 1595 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Pack, O. M. Alper, K. Stromberg, M. Augustus, M. Ozdemirli, A. M. Miermont, G. Klus, M. Rusin, R. Slack, N. F. Hacker, et al. Simultaneous Suppression of Epidermal Growth Factor Receptor and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line Cancer Res., February 1, 2004; 64(3): 789 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Okabe, A. Eguchi, R. Wadhwa, R. Rakwal, R. Tsukinoki, T. Hayakawa, and M. Nakanishi Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts Hum. Mol. Genet., February 1, 2004; 13(3): 285 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, R. L. Tomlinson, A. A. Lukowiak, R. M. Terns, and M. P. Terns Telomerase RNA Accumulates in Cajal Bodies in Human Cancer Cells Mol. Biol. Cell, January 1, 2004; 15(1): 81 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Altan-Bonnet, R. D. Phair, R. S. Polishchuk, R. Weigert, and J. Lippincott-Schwartz A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis PNAS, November 11, 2003; 100(23): 13314 - 13319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chang, J. N. Dynek, and S. Smith TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres Genes & Dev., June 1, 2003; 17(11): 1328 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Augustin, C. Spenlehauer, H. Dumond, J. Menissier-de Murcia, M. Piel, A.-C. Schmit, F. Apiou, J.-L. Vonesch, M. Kock, M. Bornens, et al. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression J. Cell Sci., April 15, 2003; 116(8): 1551 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kanai, W.-M. Tong, E. Sugihara, Z.-Q. Wang, K. Fukasawa, and M. Miwa Involvement of Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribosyl)ation in Regulation of Centrosome Function Mol. Cell. Biol., April 1, 2003; 23(7): 2451 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bae, J. R. Donigian, and A. J. W. Hsueh Tankyrase 1 Interacts with Mcl-1 Proteins and Inhibits Their Regulation of Apoptosis J. Biol. Chem., February 7, 2003; 278(7): 5195 - 5204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cronshaw, A. N. Krutchinsky, W. Zhang, B. T. Chait, and M. J. Matunis Proteomic analysis of the mammalian nuclear pore complex J. Cell Biol., September 3, 2002; 158(5): 915 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Sbodio and N.-W. Chi Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1. NuMA CONTAINS THIS RXXPDG MOTIF AND IS A NOVEL TANKYRASE PARTNER J. Biol. Chem., August 23, 2002; 277(35): 31887 - 31892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Seimiya and S. Smith The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182) J. Biol. Chem., April 12, 2002; 277(16): 14116 - 14126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Cook, J. N. Dynek, W. Chang, G. Shostak, and S. Smith Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres Mol. Cell. Biol., January 1, 2002; 22(1): 332 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Benard, B. McCright, Y. Zhang, S. Felkai, B. Lakowski, and S. Hekimi The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length Development, October 15, 2001; 128(20): 4045 - 4055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Belgareh, G. Rabut, S. W. Bai, M. van Overbeek, J. Beaudouin, N. Daigle, O. V. Zatsepina, F. Pasteau, V. Labas, M. Fromont-Racine, et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells J. Cell Biol., September 17, 2001; 154(6): 1147 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Shay, Y. Zou, E. Hiyama, and W. E. Wright Telomerase and cancer Hum. Mol. Genet., April 1, 2001; 10(7): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ludwig, G. Saretzki, P. S. Holm, F. Tiemann, M. Lorenz, T. Emrich, C. B. Harley, and T. von Zglinicki Ribozyme Cleavage of Telomerase mRNA Sensitizes Breast Epithelial Cells to Inhibitors of Topoisomerase Cancer Res., April 1, 2001; 61(7): 3053 - 3061. [Abstract] [Full Text]
|
|
|
|
|
|
M. Campbell, G. Chan, and T. Yen Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase J. Cell Sci., January 3, 2001; 114(5): 953 - 963. [Abstract] [PDF]
|
|
|
|
|
|
A. A. Gineitis, I. A. Zalenskaya, P. M. Yau, E. M. Bradbury, and A. O. Zalensky Human Sperm Telomere-binding Complex Involves Histone H2B and Secures Telomere Membrane Attachment J. Cell Biol., December 27, 2000; 151(7): 1591 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hultén, T. Lock, and T. de Lange Mammalian Meiotic Telomeres: Protein Composition and Redistribution in Relation to Nuclear Pores Mol. Biol. Cell, December 1, 2000; 11(12): 4189 - 4203. [Abstract] [Full Text]
|
|
|
|
|
|
S. Evans and V Lundblad Positive and negative regulation of telomerase access to the telomere J. Cell Sci., January 10, 2000; 113(19): 3357 - 3364. [Abstract] [PDF]
|
|
|
|
|
|
E. B. Affar, M. Germain, E. Winstall, M. Vodenicharov, R. G. Shah, G. S. Salvesen, and G. G. Poirier Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis J. Biol. Chem., January 19, 2001; 276(4): 2935 - 2942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-W. Chi and H. F. Lodish Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles J. Biol. Chem., December 1, 2000; 275(49): 38437 - 38444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Lyons, R. Deane, D. K. Lynch, Z.-S. J. Ye, G. M. Sanderson, H. J. Eyre, G. R. Sutherland, and R. J. Daly Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14 J. Biol. Chem., May 11, 2001; 276(20): 17172 - 17180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Kaminker, S.-H. Kim, R. D. Taylor, Y. Zebarjadian, W. D. Funk, G. B. Morin, P. Yaswen, and J. Campisi TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression J. Biol. Chem., September 14, 2001; 276(38): 35891 - 35899. [Abstract] [Full Text] [PDF]
|
|
