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Journal of Cell Science, Vol 112, Issue 13 2203-2211, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

The Drosophila forked protein induces the formation of actin fiber bundles in vertebrate cells

S Grieshaber and NS Petersen
Department of Molecular Biology, University of Wyoming, Laramie, WY, USA.

The forked protein is an actin binding protein involved in the formation of large actin fiber bundles in developing Drosophila bristles. These are the largest example of a type of actin bundle characterized by parallel, hexagonally packed actin fibers, also found in intestinal microvilli, kidney proximal tubule microvilli, and stereocilia in the ear. Understanding how these structures are constructed and how that construction is regulated is an important question in cell and developmental biology. Because the timing of forked gene expression coincides with the formation of the actin fiber bundles, and since the forked protein is localized at the site of initiation of these bundles before they form, it has been proposed that the forked protein is an initiator of actin bundle formation. In this paper we show that the forked protein can induce the formation of bundles and increase actin polymerization in vertebrate cells. We use this system to identify regions of the forked protein which are essential for bundle formation and actin co-localization.


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© The Company of Biologists Ltd 1999