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Journal of Cell Science, Vol 11, 261-274, Copyright © 1972 by Company of Biologists

Submitted on October 25, 1971

Absence of Metabolic Co-Operation between Certain Types of Mammalian Cells in Culture

CHANTAL WIDMER-FAVRE 1

1 Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

A mutant line of BHK21 cells lacking inosinic pyrophosphorylase activity (IPP- cells) does not incorporate [3H]hypoxanthine as opposed to wild type BHK cells. When IPP+ and IPP- cells are grown together in the presence of [3H]hypoxanthine IPP- cells in contact with IPP+ cells incorporate the marker, as seen by autoradiography. This phenomenon is known as ‘metabolic co-operation’

.

In the present work no co-operation was detected between wild type BHK cells and BHK cells lacking thymidine kinase activity (TK- cells -- they do not incorporate [3H]thymidine; between wild type L cells and L-TK- cells, or between L cells and L-IPP- cells. And there is no interaction in mixed cultures of mast cells and mast-cells-IPP-.

Submitted on October 25, 1971




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© The Company of Biologists Ltd 1972