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Journal of Cell Science, Vol 108, Issue 11 3501-3508, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
Y Wang and B Rose
Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101, USA.
Cell-to-cell channels are often seen clustered at cell-cell contacts into the so-called gap junction plaques. The mechanism of this clustering is unknown. We show that the clustering of cell-to-cell channels composed of connexin43 is induced by elevation of cyclic AMP. The cAMP-induced clustering is enhanced by inhibition of glycosylation and abolished by disruption of microfilaments. Channel clustering thus seems to be regulated by cAMP and glycosylation and to involve microfilaments.
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