|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 106, Issue 4 1139-1152, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
WK Song, W Wang, H Sato, DA Bielser and SJ Kaufman
Department of Cell and Structural Biology, University of Illinois, Urbana 61801.
We recently reported the cloning and sequencing of the alpha 7 integrin chain and its regulated expression during the development of skeletal muscle (Song et al. (1992) J. Cell Biol. 117, 643-657). The alpha 7 chain is expressed during the development of the myogenic lineage and on adult muscle fibers and this suggests that it participates in multiple and diverse functions at different times during muscle development. One interesting portion of this isoform is its cytoplasmic domain; comprised of 77 amino acids it is the largest in the alpha chains thus reported. In these experiments we begin to study the potential functions of the alpha 7 cytoplasmic domain by analyzing homologies between the rat and human sequences, by immunologic studies using an anti-cytoplasmic domain antiserum, and by identifying two alternate forms. In keeping with the nomenclature used to describe the alpha 3 and alpha 6 alternate cytoplasmic domains, we refer to the originally reported species as alpha 7B and the two additional forms as alpha 7A and alpha 7C. These three cytoplasmic domains likely arise as a consequence of alternate splicing. A splice site at the junctions of the transmembrane and cytoplasmic domains is used to generate the alpha 3, alpha 6 and alpha 7 A and B forms. The alpha 7A form RNA contains an additional 113 nucleotides compared to the B form, and a common coding region in the A and B form RNAs is used in alternate reading frames. Part of the coding region of alpha 7B appears to be used as the 3'-untranslated region of the alpha 7A form. The alpha 7C mRNA is 595 nucleotides smaller than the alpha 7B RNA and part of the 3'-untranslated region of the alpha 7B isoform is used as coding sequence in alpha 7C. There is developmental specificity in expression of these alternate mRNAs: alpha 7A and alpha 7C transcripts are found upon terminal myogenic differentiation whereas alpha 7B is present earlier in replicating cells and diminishes upon differentiation. We suggest this selective expression of the alpha 7 cytoplasmic domains underlies the diversity in function of the alpha 7 beta 1 integrin at different stages of muscle development. Immunochemical analyses indicate that the alpha 7B cytoplasmic domain undergoes a change in conformation in response to binding laminin or upon crosslinking initiated with antibody reactive with the integrin extracellular domain. Crosslinking also promotes association of the integrin with the cell cytoskeleton.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  R. A. Peat, J. M. Smith, A. G. Compton, N. L. Baker, R. A. Pace, D. J. Burkin, S. J. Kaufman, S. R. Lamande, and K. N. North Diagnosis and etiology of congenital muscular dystrophy Neurology, July 29, 2008; 71(5): 312 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Elsherif, M. S. Huang, S.-Y. Shai, Y. Yang, R. Y. Li, J. Chun, M. A. Mekany, A. L. Chu, S. J. Kaufman, and R. S. Ross Combined Deficiency of Dystrophin and {beta}1 Integrin in the Cardiac Myocyte Causes Myocardial Dysfunction, Fibrosis and Calcification Circ. Res., May 9, 2008; 102(9): 1109 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, D. J. Burkin, and S. J. Kaufman Increasing {alpha}7{beta}1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression Am J Physiol Cell Physiol, February 1, 2008; 294(2): C627 - C640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Samson, C. Will, A. Knoblauch, L. Sharek, K. von der Mark, K. Burridge, and V. Wixler Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain {alpha}7A and Influences Myoblast Differentiation J. Biol. Chem., May 25, 2007; 282(21): 15730 - 15742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Milner and S. J. Kaufman {alpha}7{beta}1 Integrin Does Not Alleviate Disease in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2F Am. J. Pathol., February 1, 2007; 170(2): 609 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Boppart, D. J. Burkin, and S. J. Kaufman {alpha}7beta1-Integrin regulates mechanotransduction and prevents skeletal muscle injury Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1660 - C1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zolkiewska Ecto-ADP-ribose Transferases: Cell-Surface Response to Local Tissue Injury Physiology, December 1, 2005; 20(6): 374 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lopez, U. Mayer, W. Hwang, T. Taylor, M. A. Hashmi, S. R. Jannapureddy, and A. M. Boriek Force transmission, compliance, and viscoelasticity are altered in the {alpha}7-integrin-null mouse diaphragm Am J Physiol Cell Physiol, February 1, 2005; 288(2): C282 - C289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Burkin, G. Q. Wallace, D. J. Milner, E. J. Chaney, J. A. Mulligan, and S. J. Kaufman Transgenic Expression of {alpha}7{beta}1 Integrin Maintains Muscle Integrity, Increases Regenerative Capacity, Promotes Hypertrophy, and Reduces Cardiomyopathy in Dystrophic Mice Am. J. Pathol., January 1, 2005; 166(1): 253 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Samson, N. Smyth, S. Janetzky, O. Wendler, J. M. Muller, R. Schule, H. von der Mark, K. von der Mark, and V. Wixler The LIM-only Proteins FHL2 and FHL3 Interact with {alpha}- and {beta}-Subunits of the Muscle {alpha}7{beta}1 Integrin Receptor J. Biol. Chem., July 2, 2004; 279(27): 28641 - 28652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-T. Chao, G. A. Meininger, J. L. Patterson, S. A. L. Jones, C. R. Partridge, J. D. Neiger, E. S. Williams, S. J. Kaufman, K. S. Ramos, and E. Wilson Regulation of {alpha}7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H381 - H389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Kim, M. S. Kwon, C. S. Park, K.-R. Choi, J.-S. Chun, J. Ahn, and W. K. Song Modulation of Thr Phosphorylation of Integrin {beta}1 during Muscle Differentiation J. Biol. Chem., February 20, 2004; 279(8): 7082 - 7090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-G. Yeh, B. L. Ziober, B. Liu, G. Lipkina, I. S. Vizirianakis, and R. H. Kramer The {beta}1 Cytoplasmic Domain Regulates the Laminin-binding Specificity of the {alpha}7X1 Integrin Mol. Biol. Cell, September 1, 2003; 14(9): 3507 - 3518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Mayer Integrins: Redundant or Important Players in Skeletal Muscle? J. Biol. Chem., April 18, 2003; 278(17): 14587 - 14590. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nawrotzki, M. Willem, N. Miosge, H. Brinkmeier, and U. Mayer Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice Hum. Mol. Genet., March 1, 2003; 12(5): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaariainen, L. Nissinen, S. Kaufman, A. Sonnenberg, M. Jarvinen, J. Heino, and H. Kalimo Expression of {alpha}7{beta}1 Integrin Splicing Variants during Skeletal Muscle Regeneration Am. J. Pathol., September 1, 2002; 161(3): 1023 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Pegoraro, F. Cepollaro, P. Prandini, A. Marin, M. Fanin, C. P. Trevisan, A. H. El-Messlemani, G. Tarone, E. Engvall, E. P. Hoffman, et al. Integrin {alpha}7{beta}1 in Muscular Dystrophy/Myopathy of Unknown Etiology Am. J. Pathol., June 1, 2002; 160(6): 2135 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. von der Mark, I. Williams, O. Wendler, L. Sorokin, K. von der Mark, and E. Poschl Alternative Splice Variants of alpha 7beta 1 Integrin Selectively Recognize Different Laminin Isoforms J. Biol. Chem., February 15, 2002; 277(8): 6012 - 6016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bouvard, C. Brakebusch, E. Gustafsson, A. Aszodi, T. Bengtsson, A. Berna, and R. Fassler Functional Consequences of Integrin Gene Mutations in Mice Circ. Res., July 30, 2001; 89(3): 211 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ross and T. K. Borg Integrins and the Myocardium Circ. Res., June 8, 2001; 88(11): 1112 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Burkin, G. Q. Wallace, K. J. Nicol, D. J. Kaufman, and S. J. Kaufman Enhanced Expression of the {alpha}7{beta}1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic Mice J. Cell Biol., March 19, 2001; 152(6): 1207 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Maitra, I. L. Flink, J. J. Bahl, and E. Morkin Expression of {alpha} and {beta} integrins during terminal differentiation of cardiomyocytes Cardiovasc Res, September 1, 2000; 47(4): 715 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kwon, C. S. Park, K.-r. Choi, C.-S. Park, J. Ahnn, J. I. Kim, S. H. Eom, S. J. Kaufman, and W. K. Song Calreticulin Couples Calcium Release and Calcium Influx in Integrin-mediated Calcium Signaling Mol. Biol. Cell, April 1, 2000; 11(4): 1433 - 1443. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Burkin, J. Kim, M Gu, and S. Kaufman Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors J. Cell Sci., January 8, 2000; 113(16): 2877 - 2886. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Burkin, M. Gu, B. L. Hodges, J. T. Campanelli, and S. J. Kaufman A Functional Role for Specific Spliced Variants of the alpha 7beta 1 Integrin in Acetylcholine Receptor Clustering J. Cell Biol., November 16, 1998; 143(4): 1067 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gimond, C. Baudoin, R. van der Neut, D. Kramer, J. Calafat, and A. Sonnenberg Cre-loxP-mediated Inactivation of the alpha 6A Integrin Splice Variant In Vivo: Evidence for a Specific Functional Role of alpha 6A in Lymphocyte Migration but Not in Heart Development J. Cell Biol., October 5, 1998; 143(1): 253 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Russo, D Tomatis, G Collo, G Tarone, and F Tato Myogenic conversion of NIH3T3 cells by exogenous MyoD family members: dissociation of terminal differentiation from myotube formation J. Cell Sci., January 3, 1998; 111(6): 691 - 700. [Abstract] [PDF]
|
|
|
|
|
|
S. S. Veiga, M. C. Q. B. Elias, W. Gremski, M. A. Porcionatto, R. da Silva, H. B. Nader, and R. R. Brentani Post-translational Modifications of alpha 5beta 1 Integrin by Glycosaminoglycan Chains. THE alpha 5beta 1 INTEGRIN IS A FACULTATIVE PROTEOGLYCAN J. Biol. Chem., May 9, 1997; 272(19): 12529 - 12535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hodges, Y. Hayashi, I Nonaka, W Wang, K Arahata, and S. Kaufman Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies J. Cell Sci., January 11, 1997; 110(22): 2873 - 2881. [Abstract] [PDF]
|
|
|
|
|
|
C.-C. Yao, B. L. Ziober, R. M. Squillace, and R. H. Kramer alpha 7 Integrin Mediates Cell Adhesion and Migration on Specific Laminin Isoforms J. Biol. Chem., October 11, 1996; 271(41): 25598 - 25603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Ziober and R. H. Kramer Identification and Characterization of the Cell Type-specific and Developmentally Regulated alpha 7 Integrin Gene Promoter J. Biol. Chem., September 13, 1996; 271(37): 22915 - 22922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Echtermeyer, S. Schöber, E. Pöschl, H. von der Mark, and K. von der Mark Specific Induction of Cell Motility on Laminin by alpha7 Integrin J. Biol. Chem., January 26, 1996; 271(4): 2071 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yao, B. Ziober, A. Sutherland, D. Mendrick, and R. Kramer Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor J. Cell Sci., January 12, 1996; 109(13): 3139 - 3150. [Abstract] [PDF]
|
|
|
|
|
|
A. Zolkiewska and J. Moss Processing of ADP-ribosylated Integrin [IMAGE]7 in Skeletal Muscle Myotubes J. Biol. Chem., April 21, 1995; 270(16): 9227 - 9233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Cattelino, R Longhi, and I de Curtis Differential distribution of two cytoplasmic variants of the alpha 6 beta 1 integrin laminin receptor in the ventral plasma membrane of embryonic fibroblasts J. Cell Sci., January 9, 1995; 108(9): 3067 - 3078. [Abstract] [PDF]
|
|
|
|
|
|
M Gu, W Wang, W. Song, D. Cooper, and S. Kaufman Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation J. Cell Sci., January 1, 1994; 107(1): 175 - 181. [Abstract] [PDF]
|
|
|
|
|
|
D. Mielenz, S. Hapke, E. Poschl, H. von der Mark, and K. von der Mark The Integrin alpha 7 Cytoplasmic Domain Regulates Cell Migration, Lamellipodia Formation, and p130CAS/Crk Coupling J. Biol. Chem., April 13, 2001; 276(16): 13417 - 13426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. McDearmon, A. C. Combs, and J. M. Ervasti Differential Vicia villosa Agglutinin Reactivity Identifies Three Distinct Dystroglycan Complexes in Skeletal Muscle J. Biol. Chem., September 7, 2001; 276(37): 35078 - 35086. [Abstract] [Full Text] [PDF]
|
|
