spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stone, J. S.
Right arrow Articles by Cotanche, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stone, J. S.
Right arrow Articles by Cotanche, D. A.

Journal of Cell Science, Vol 102, Issue 4 671-680, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Synchronization of hair cell regeneration in the chick cochlea following noise damage

JS Stone and DA Cotanche
Department of Anatomy & Neurobiology, Boston University School of Medicine, MA 02118.

Pure-tone overstimulation for prolonged time leads to hair cell death in frequency-specific regions of the cochlear epithelium. Unlike mammals, birds replace missing hair cells by stimulating mitosis in an uncharacterized precursor cell. Regenerated hair cells, initially identifiable by their immature stereocilia and small surface areas, differentiate into mature cells in a manner which parallels embryonic development. In the current study, we examined whether hair cell regeneration is initiated during noise exposure or after the end of acoustic trauma. We exposed 7-to 15-day-old chicks to a 1500 Hz pure tone at 120 dB SPL (re 20 muPa) for 4, 12, and 24 hours and examined the recovering cochlear epithelium with scanning electron microscopy to determine when regenerated hair cells were first identifiable. The earliest evidence of new hair cells appeared roughly 96 hours after the onset of 4-, 12-, and 24-hour exposures. Our previous studies initially identified new hair cells 96 hours after the start of a 48-hour exposure. Therefore, hair cell regeneration follows a similar time course relative to the onset of noise exposure, regardless of the ultimate duration of exposure. Since we estimate that hair cells take at least 48 hours after their genesis to form immature stereocilia, the signal which induces hair cell precursors to re-enter the cell cycle and to divide probably has its initial effects very early during the exposure period. (A previous report of these data was given at the 1991 American Society for Cell Biology conference.)


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
M. E. Smith, A. B. Coffin, D. L. Miller, and A. N. Popper
Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure
J. Exp. Biol., November 1, 2006; 209(21): 4193 - 4202.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. S. Stone and E. W Rubel
Cellular studies of auditory hair cell regeneration in birds
PNAS, October 24, 2000; 97(22): 11714 - 11721.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. K. Hennig and D. A. Cotanche
Regeneration of Cochlear Efferent Nerve Terminals after Gentamycin Damage
J. Neurosci., May 1, 1998; 18(9): 3282 - 3296.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
E Hashino and R. Salvi
Changing spatial patterns of DNA replication in the noise-damaged chick cochlea
J. Cell Sci., January 5, 1993; 105(1): 23 - 31.
[Abstract] [PDF]


© The Company of Biologists Ltd 1992