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Journal of Cell Science, Vol 101, Issue 2 333-342, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Bone-marrow-derived chondrogenesis in vitro

L Berry, ME Grant, J McClure and P Rooney
Department of Biochemistry and Molecular Biology, University of Manchester, Medical School, UK.

Bone marrow stromal cells from embryonic, neo-natal and adult chickens were grown in vitro over a 21-day period. Marrow stromal cells from embryonic and neonatal chicks produced clonally derived chondrocytic colonies. The cells within the colonies were surrounded by a refractile, Alcian-blue-positive matrix and their cartilagenous nature was shown biochemically and immunocytochemically by the synthesis of collagen types II and X. The ability of chick bone marrow cells to form chondrocytic colonies decreased during development and was lost by adulthood. In addition to chondrocytic colonies, fat cells and fibroblasts were also observed in the cultures. Our data demonstrate that chick bone marrow stroma contains cells that are capable of differentiating along different pathways within the same culture, providing further evidence for the presence in bone marrow of a stromal stem cell.


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© The Company of Biologists Ltd 1992