spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by STOKER, M. G. P.
Right arrow Articles by O'NEILL, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STOKER, M. G. P.
Right arrow Articles by O'NEILL, C.

Journal of Cell Science, Vol 1, 297-310, Copyright © 1966 by Company of Biologists

Submitted on March 12, 1966

Growth Inhibition of Polyoma-Transformed Cells by Contact with Static Normal Fibroblasts

M. G. P. STOKER 1, MOIRA SHEARER 1, and C. O'NEILL 1

1 Medical Research Council Experimental Virus Research Unit, Institute of Virology, University of Glasgow

The growth of polyoma-transformed BHK21 cells was studied in mixed cultures with normal mouse fibroblasts. On coverslips in excess medium, normal fibroblasts undergo one or two divisions after the cells become contiguous. Py-cell growth was not inhibited by contact with confluent fibroblasts which were still dividing, but the Py cells were rapidly inhibited after contact with fibroblasts which had become static. Further experiments confirmed the earlier view that the inhibitory effect was not due to a general change in the medium but was only brought about when cells were in contact or close proximity.

Submitted on March 12, 1966




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Rubin
Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype
PNAS, April 29, 2008; 105(17): 6215 - 6221.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Pennington, B. J. Foster, S. R. Hawley, R. E. Jenkins, O. Zolle, M. R. H. White, C. J. McNamee, P. Sheterline, and A. W. M. Simpson
Cell Shape-dependent Control of Ca2+ Influx and Cell Cycle Progression in Swiss 3T3 Fibroblasts
J. Biol. Chem., November 2, 2007; 282(44): 32112 - 32120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. F. Redente, D. J. Orlicky, R. J. Bouchard, and A. M. Malkinson
Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice
Am. J. Pathol., February 1, 2007; 170(2): 693 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. B. Alexander, H. Ichikawa, J. F. Bechberger, V. Valiunas, M. Ohki, C. C. G. Naus, T. Kunimoto, H. Tsuda, W. T. Miller, and G. S. Goldberg
Normal Cells Control the Growth of Neighboring Transformed Cells Independent of Gap Junctional Communication and Src Activity
Cancer Res., February 15, 2004; 64(4): 1347 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. J. Sawey
Role of Gap-Junctional Communication in Breast Cancer Progression and Chemoprevention
J. Nutr., January 1, 2001; 131(1): 167S - 169.
[Full Text]

Home page
 ScienceHome page
H. Herschman and D. Brankow
Ultraviolet irradiation transforms C3H10T1/2 cells to a unique, suppressible phenotype
Science, December 12, 1986; 234(4782): 1385 - 1388.
[Abstract] [PDF]

Home page
 ScienceHome page
H. J.-P. Ryser
Uptake of Protein by Mammalian Cells: An Underdeveloped Area: The penetration of foreign proteins into mammalian cells can be measured and their functions explored
Science, January 26, 1968; 159(3813): 390 - 396.
[Abstract] [PDF]


© The Company of Biologists Ltd 1966