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Figure 5


Fig. 5. The role of PI3K{gamma} in mediating in vivo recruitment and chemotaxis in response to fMLP. Mice are either wild type (C57Bl/6) or PI3K{gamma}–/– (PI3K{gamma} KO). (a) Number of rolling cells passing through the blood vessel per minute. (b) Number of neutrophils adhering to the endothelium per 100 µm of blood vessel. (c) Number of neutrophils emigrating from a single blood vessel, within one field of view. (d) Directionality (C.I.) of in vivo neutrophil migration to fMLP. (e) Speed of in vivo neutrophil migration to fMLP. (f) Delay between emigration and initiation of chemotaxis in vivo in response to fMLP. n>4 for all data; *P<0.05, Student's t-test.