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Figure 4


Fig. 4. The role of p38 MAPK during neutrophil chemotaxis to fMLP. (a) Human neutrophils treated with the p38 MAPK inhibitor SB20580 did not chemotax to fMLP in a long-term chemotactic assay. (b) Murine neutrophils treated with the p38 MAPK inhibitor SB203580, or deficient in MK2, did not chemotax to fMLP in a long-term chemotactic assay. (c) Murine neutrophils treated with the p38 MAPK inhibitor SB203580, or deficient in MK2, did not polarize in response to fMLP. n=4 for all data; *P<0.05, ANOVA with Bonferroni's correction.