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Figure 2


Fig. 2. The role of PI3K in mediating initial responses to fMLP and IL8. Human neutrophils were either uninhibited or treated with a pan-PI3K inhibitor (LY294002). fMLP or IL8 was added at time=0 and the cells monitored for 20 minutes. (a) Percentage of cells that polarized in response to fMLP. (b) Percentage of cells orientated towards the source of fMLP. (c) Speed of migration in response to fMLP. (d) Percentage of cells polarized in response to IL8. (e) Percentage of cells orientated towards the source of IL8. (f) Speed of migration in response to IL8. n=4 for all data.