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Figure 4


Fig. 4. Line-scan imaging of the ET-induced enhancement of nuclear CaTs. (A) Original line-scan images and normalised fluorescence traces of the cytoplasmic (black) and nuclear (red) CaTs in an atrial myocyte before (Control) and following a 10 minute exposure to 10 nM ET. The cell scheme illustrates the position of the scan line. Bars (at right), 5 µm. (B) Average values of the effects of 10 nM ET on peak systolic [Ca2+] (normalised to the pre-ET control), time to peak and the time constant {tau} for decay in the cytoplasm (black) and the nucleus (red). Means ± s.e.m. of five atrial myocytes.