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Figure 2


Fig. 2. Transgenic {alpha}-dystrobrevin is functional when expressed in the {alpha}-dystrobrevin-null mouse. (A) H&E-stained tibialis anterior (TA) muscle shows that transgene expression in the dystrobrevin-null mouse results in a more uniform fiber diameter and a reduction in the number of centrally nucleated fibers. (B) The number of centrally nucleated fibers in TA (dark shade), soleus (medium shade) and diaphragm (light shade) muscles are reduced by expression of each {alpha}-dystrobrevin transgene. (C) Serum creatine kinase levels were likewise restored to normal with transgene expression. Data are from transgenic lines 63 (DB) and 29 (DB-RPS). Error bars give ± s.d. Scale bar, 50 µm.