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Figure 1


Fig. 1. (A) Diagram of a myosin molecule showing the globular head region, the {alpha}-helical coiled-coil rod and the short non-helical tail (NHT). The subfragment-1 (S-1), rod and heavy meromyosin (HMM) proteolytic domains are also indicated. (B) An example of a bipolar filament, which is formed by interaction among the rod domains. (C) Regulation of myosin activity by phosphorylation of MLC20 of NMII by MLCK and Rho kinase. Whereas MLCK can only phosphorylate MLC20, Rho kinase can phosphorylate MLC20 and also a subunit of myosin phosphatase (MYPT1). Phosphorylation by Rho kinase activates myosin and inactivates MYPT. Both result in an increase in phosphorylated MLC20 and activation of myosin.