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Figure 2


Fig. 2. Signaling by CCN family members. CCN1, CCN2 and CCN3 bind TGFß, fibronectin, integrins, LRP1 and HSPGs as indicated. CCN proteins appear to signal principally through the C-terminal quarter (domain IV) to activate adhesive signaling pathways and hence amplify responses to TGFß or fibronectin.